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在重症监护病房中,CIWA-Ar 是否应该成为酒精戒断综合征的标准监测策略?

Should the CIWA-Ar be the standard monitoring strategy for alcohol withdrawal syndrome in the intensive care unit?

机构信息

Seattle-Denver Center of Innovation (COIN), VA Puget Sound Health Care System, Seattle Division, 1660 South Columbian Way S-152, SeattleSeattle, WA, 98108, USA.

Division of Pulmonary, Critical Care, & Sleep Medicine, University of Washington, Seattle, WA, USA.

出版信息

Addict Sci Clin Pract. 2021 Mar 24;16(1):21. doi: 10.1186/s13722-021-00226-w.


DOI:10.1186/s13722-021-00226-w
PMID:33762020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7988382/
Abstract

BACKGROUND: The Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) is commonly used in hospitals to titrate medications for alcohol withdrawal syndrome (AWS), but may be difficult to apply to intensive care unit (ICU) patients who are too sick or otherwise unable to communicate. OBJECTIVES: To evaluate the frequency of CIWA-Ar monitoring among ICU patients with AWS and variation in CIWA-Ar monitoring across patient demographic and clinical characteristics. METHODS: The study included all adults admitted to an ICU in 2017 after treatment for AWS in the Emergency Department of an academic hospital that standardly uses the CIWA-Ar to assess AWS severity and response to treatment. Demographic and clinical data, including Richmond Agitation-Sedation Scale (RASS) assessments (an alternative measure of agitation/sedation), were obtained via chart review. Associations between patient characteristics and CIWA-Ar monitoring were tested using logistic regression. RESULTS: After treatment for AWS, only 56% (n = 54/97) of ICU patients were evaluated using the CIWA-Ar; 94% of patients had a documented RASS assessment (n = 91/97). Patients were significantly less likely to receive CIWA-Ar monitoring if they were intubated or identified as Black. CONCLUSIONS: CIWA-Ar monitoring was used inconsistently in ICU patients with AWS and completed less often in those who were intubated or identified as Black. These hypothesis-generating findings raise questions about the utility of the CIWA-Ar in ICU settings. Future studies should assess alternative measures for titrating AWS medications in the ICU that do not require verbal responses from patients and further explore the association of race with AWS monitoring.

摘要

背景:临床酒精戒断评估修订版(CIWA-Ar)常用于医院调整酒精戒断综合征(AWS)的药物剂量,但对于病情过重或无法交流的重症监护病房(ICU)患者,可能难以应用。

目的:评估 ICU 中 AWS 患者接受 CIWA-Ar 监测的频率,以及 CIWA-Ar 监测在患者人口统计学和临床特征方面的变化。

方法:该研究纳入了 2017 年在学术医院急诊科接受 AWS 治疗后转入 ICU 的所有成年人,该医院标准使用 CIWA-Ar 评估 AWS 严重程度和治疗反应。通过病历回顾获取人口统计学和临床数据,包括 Richmond 躁动镇静量表(RASS)评估(躁动/镇静的替代测量)。使用逻辑回归检验患者特征与 CIWA-Ar 监测之间的关联。

结果:在 AWS 治疗后,只有 56%(n=54/97)的 ICU 患者接受了 CIWA-Ar 评估;94%的患者有记录的 RASS 评估(n=91/97)。如果患者插管或被认定为黑人,他们接受 CIWA-Ar 监测的可能性显著降低。

结论:在 ICU 中接受 AWS 治疗的患者中,CIWA-Ar 监测的使用不一致,并且在插管或被认定为黑人的患者中完成的频率更低。这些产生假设的发现提出了关于 CIWA-Ar 在 ICU 环境中的实用性的问题。未来的研究应评估替代 ICU 中 AWS 药物滴定的措施,这些措施不需要患者的口头反应,并进一步探讨种族与 AWS 监测的关联。

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本文引用的文献

[1]
Implementation of a Protocol Using the 5-Item Brief Alcohol Withdrawal Scale for Treatment of Severe Alcohol Withdrawal in Intensive Care Units.

J Intensive Care Med. 2021-11

[2]
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J Addict Med. 2020

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Addressing alcohol and other drug stigma: Where to next?

Drug Alcohol Rev. 2020-2

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Evaluation of the Brief Alcohol Withdrawal Scale Protocol at an Academic Medical Center.

J Addict Med. 2019

[5]
Public Health, Racism, and the Lasting Impact of Hospital Segregation.

Public Health Rep. 2018-11

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Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Crit Care Med. 2018-9

[7]
Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome.

Am J Crit Care. 2018-7

[8]
Implementation of an ICU-Specific Alcohol Withdrawal Syndrome Management Protocol Reduces the Need for Mechanical Ventilation.

Pharmacotherapy. 2018-7

[9]
Evaluation of the appropriate use of a CIWA-Ar alcohol withdrawal protocol in the general hospital setting.

Am J Drug Alcohol Abuse. 2017-10-5

[10]
Development and implementation of an alcohol withdrawal protocol using a 5-item scale, the Brief Alcohol Withdrawal Scale (BAWS).

Subst Abus. 2017-7-12

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