Department of Clinical Mycobacteriology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan.
Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan.
Int J Tuberc Lung Dis. 2021 Apr 1;25(4):299-304. doi: 10.5588/ijtld.20.0790.
Previous studies have shown a reduction in health-related quality of life (HRQoL) in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). However, the causes of this decline and the factors that contribute to it are unknown. This study was conducted to analyse the association between the St George´s Respiratory Questionnaire (SGRQ) and clinical parameters, including age, disease duration, body composition, pulmonary function, chest X-ray findings, blood data and physical function. We performed a single-centre, cross-sectional, retrospective study of 101 patients with NTM-PD from December 2016 to October 2019. The relationship between the SGRQ scores and clinical parameters was evaluated. The median patient age was 67.0 years. Pulmonary function, radiological score, albumin levels, C-reactive protein levels and incremental shuttle walk test distance (ISWD) were significantly correlated with the total and component scores on the SGRQ. Multiple regression analysis showed that the SGRQ score was significantly associated with radiological score, pulmonary function and ISWD. This study was the first to assess the effect of clinical parameters on the SGRQ in patients with NTM-PD. HRQoL as determined using the SGRQ was associated with the radiological score, pulmonary function and ISWD in patients with NTM-PD.
先前的研究表明，非结核分枝杆菌肺病（NTM-PD）患者的健康相关生活质量（HRQoL）下降。然而，这种下降的原因和促成因素尚不清楚。本研究旨在分析圣乔治呼吸问卷（SGRQ）与临床参数之间的关系，包括年龄、疾病持续时间、身体成分、肺功能、胸部 X 线检查结果、血液数据和身体功能。我们对 2016 年 12 月至 2019 年 10 月期间的 101 例 NTM-PD 患者进行了单中心、横断面、回顾性研究。评估了 SGRQ 评分与临床参数之间的关系。中位患者年龄为 67.0 岁。肺功能、影像学评分、白蛋白水平、C 反应蛋白水平和递增穿梭步行试验距离（ISWD）与 SGRQ 的总评分和各成分评分显著相关。多元回归分析显示，SGRQ 评分与影像学评分、肺功能和 ISWD 显著相关。本研究首次评估了临床参数对 NTM-PD 患者 SGRQ 的影响。使用 SGRQ 确定的 HRQoL 与 NTM-PD 患者的影像学评分、肺功能和 ISWD 相关。
