Department of Clinical Mycobacteriology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan.
Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan.
Int J Tuberc Lung Dis. 2022 Apr 1;26(4):310-316. doi: 10.5588/ijtld.21.0527.
The presence of depressive symptoms in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) is an important research topic; however, the prevalence of depressive symptoms and the factors that influence their development are unclear. To analyse the association between CES-D (Center for Epidemiological Studies Depression Scale) scores and clinical parameters such as age, disease duration, pulmonary function, imaging findings, blood data, physical functions, sleep disturbances, respiratory symptoms and health-related quality of life (HRQOL). We conducted a cross-sectional retrospective study of 114 patients with NTM-PD at a single centre from March 2016 to January 2021 to evaluate the relationship between CES-D scores and clinical parameters. Participants had a median age of 64 years; 32.5% of them had depressive symptoms. Disease duration, albumin, C-reactive protein, pulmonary function, dyspnoea, exercise capacity, respiratory symptoms, cough-related HRQOL and sleep disturbances were associated with depressive symptoms. Binomial logistic regression analyses indicated that the CES-D score was significantly associated with cough-related HRQOL and sleep disturbances. A high percentage of NTM-PD patients in this study experienced depressive symptoms, and these patients had abnormalities of various clinical parameters. Cough-related HRQOL and sleep disturbance had a strong influence on the development of depressive symptoms.
患有非结核分枝杆菌肺病（NTM-PD）的患者出现抑郁症状是一个重要的研究课题；然而，抑郁症状的患病率以及影响其发展的因素尚不清楚。为了分析 CES-D（流行病学研究抑郁量表）评分与年龄、疾病持续时间、肺功能、影像学表现、血液数据、身体功能、睡眠障碍、呼吸症状和健康相关生活质量（HRQOL）等临床参数之间的关联。我们对 2016 年 3 月至 2021 年 1 月在一家单中心接受 NTM-PD 治疗的 114 例患者进行了一项横断面回顾性研究，以评估 CES-D 评分与临床参数之间的关系。参与者的中位年龄为 64 岁；32.5%的人有抑郁症状。疾病持续时间、白蛋白、C 反应蛋白、肺功能、呼吸困难、运动能力、呼吸症状、咳嗽相关 HRQOL 和睡眠障碍与抑郁症状有关。二项逻辑回归分析表明，CES-D 评分与咳嗽相关 HRQOL 和睡眠障碍显著相关。本研究中相当大比例的 NTM-PD 患者出现抑郁症状，且这些患者的各种临床参数存在异常。咳嗽相关 HRQOL 和睡眠障碍对抑郁症状的发展有很强的影响。
