School of Environment and Science, Griffith University, Gold Coast, QLD 4222, Australia.
School of Environment and Science, Griffith University, Gold Coast, QLD 4222, Australia; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
J Pharm Sci. 2021 Jul;110(7):2823-2832. doi: 10.1016/j.xphs.2021.03.012. Epub 2021 Mar 21.
Viable skin drug transport is an important concept to consider as it can have a significant impact on the local concentration of a drug. The concentration becomes even more critical for toxicological issues when implementing different permeability enhancement techniques. For this reason, it is important to develop models that can predict drug transport in the viable skin. This paper expands upon previous capillary modeling by representing the convective transport of a solute that has permeated into the capillary loops. As a result, convective transport caused the concentration profile to plateau within the deeper dermal layers, effectively matching the trend of previous experimental data. Furthermore, the new model also has a significantly quicker transient profile as the time required to reach steady-state is five-fold faster than predicted in previous homogenous models.
可存活皮肤中的药物输送是一个需要考虑的重要概念，因为它会对药物的局部浓度产生重大影响。在实施不同的渗透增强技术时，对于毒理学问题，浓度变得更加关键。出于这个原因，开发能够预测可存活皮肤中药物输送的模型非常重要。本文通过表示已经渗透到毛细血管环中的溶质的对流输送，对以前的毛细管建模进行了扩展。因此，对流输送导致浓度分布在更深的真皮层内达到稳定，有效地与以前的实验数据趋势相匹配。此外，新模型的瞬态分布也明显更快，因为达到稳定状态所需的时间比以前同质模型预测的快五倍。
