Targeting replication stress to tackle cancer stem cells.
作者信息
Galluzzi Lorenzo
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Sandra and Edward Meyer Cancer Center, New York, NY, USA.
出版信息
Cell Death Dis. 2021 Mar 24;12(4):315. doi: 10.1038/s41419-021-03609-8.
Abstract
摘要
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本文引用的文献
1
Intratumoral heterogeneity in cancer progression and response to immunotherapy.
Nat Med. 2021 Feb;27(2):212-224. doi: 10.1038/s41591-021-01233-9. Epub 2021 Feb 11.
2
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Cell Death Differ. 2021 Jul;28(7):2060-2082. doi: 10.1038/s41418-020-00733-4. Epub 2021 Feb 2.
3
Immunomodulation by targeted anticancer agents.
Cancer Cell. 2021 Mar 8;39(3):310-345. doi: 10.1016/j.ccell.2020.11.009. Epub 2020 Dec 17.
4
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy.
Nat Immunol. 2020 Oct;21(10):1160-1171. doi: 10.1038/s41590-020-0751-0. Epub 2020 Aug 3.
5
State-of-the-art strategies for targeting the DNA damage response in cancer.
Nat Rev Clin Oncol. 2019 Feb;16(2):81-104. doi: 10.1038/s41571-018-0114-z.
6
Stem cell fate in cancer growth, progression and therapy resistance.
Nat Rev Cancer. 2018 Nov;18(11):669-680. doi: 10.1038/s41568-018-0056-x.
7
Cancer stem cells revisited.
Nat Med. 2017 Oct 6;23(10):1124-1134. doi: 10.1038/nm.4409.
8
DNA Damage in Stem Cells.
Mol Cell. 2017 May 4;66(3):306-319. doi: 10.1016/j.molcel.2017.04.006.
9
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
Gut. 2018 May;67(5):903-917. doi: 10.1136/gutjnl-2016-312623. Epub 2017 Apr 7.
10
Replication stress and cancer.
Nat Rev Cancer. 2015 May;15(5):276-89. doi: 10.1038/nrc3916.
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