Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Sevilla 41092, Spain.
Nat Rev Cancer. 2015 May;15(5):276-89. doi: 10.1038/nrc3916.
Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable cellular process that can lead to it. Any condition leading to high levels of DNA damage will result in replication stress, which is a source of genome instability and a feature of pre-cancerous and cancerous cells. Therefore, understanding the molecular basis of replication stress is crucial to the understanding of tumorigenesis. Although a negative aspect of replication stress is its prominent role in tumorigenesis, a positive aspect is that it provides a potential target for cancer therapy. In this Review, we discuss the link between persistent replication stress and tumorigenesis, with the goal of shedding light on the mechanisms underlying the initiation of an oncogenic process, which should open up new possibilities for cancer diagnostics and treatment.
基因组不稳定性是癌症的一个标志，而 DNA 复制是最易受损的细胞过程，可导致基因组不稳定。任何导致高水平 DNA 损伤的情况都会导致复制应激，这是基因组不稳定的来源，也是癌前和癌细胞的特征。因此，了解复制应激的分子基础对于理解肿瘤发生至关重要。尽管复制应激的一个负面方面是其在肿瘤发生中的突出作用，但一个积极方面是它为癌症治疗提供了一个潜在的靶点。在这篇综述中，我们讨论了持续的复制应激与肿瘤发生之间的联系，旨在阐明致癌过程启动的机制，这应该为癌症诊断和治疗开辟新的可能性。
