Wang Zhicheng, Li Yumin, Zhang Tong, Li Hongxia, Yang Zhao, Wang Cheng
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Qingdao Institute for Food and Drug Control, Qingdao, China.
Front Pharmacol. 2021 Mar 8;12:632877. doi: 10.3389/fphar.2021.632877. eCollection 2021.
Insufficient transport of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Block copolymers are promising carriers with smaller particle size by ratio modification. Here, we constructed cisplatin nanoparticles with sizes ranging from 8 to 40 nm to study the permeability and therapy of Lewis lung carcinoma. We synthesized methoxypoly(ethylene glycol)-block poly(L-glutamic acid sodium salt) loading cisplatin through complexation reaction. The cisplatin nanomedicine has high drug loading and encapsulation efficiency. data demonstrated that cisplatin nanoparticles had equivalent growth-inhibiting effects on Lewis lung carcinoma cells compared to free cisplatin. evidences showed cisplatin nanoparticles had superior antitumor effects on the Lewis lung carcinoma mouse model with no obvious side effects. All results indicated that optimizing the ratio of block copolymers to obtain smaller sized nanomedicine could act as a promising strategy for overcoming the inadequate accumulation in poorly vascularized tumors.
治疗性药物向肿瘤床的运输不足是癌症纳米医学的一个瓶颈。通过比例修饰，嵌段共聚物是具有较小粒径的有前景的载体。在此，我们构建了尺寸范围为8至40纳米的顺铂纳米颗粒，以研究Lewis肺癌的渗透性和治疗效果。我们通过络合反应合成了负载顺铂的甲氧基聚（乙二醇）-嵌段聚（L-谷氨酸钠盐）。顺铂纳米药物具有高载药量和包封率。数据表明，与游离顺铂相比，顺铂纳米颗粒对Lewis肺癌细胞具有同等的生长抑制作用。证据显示，顺铂纳米颗粒对Lewis肺癌小鼠模型具有优异的抗肿瘤作用，且无明显副作用。所有结果表明，优化嵌段共聚物的比例以获得更小尺寸的纳米药物可能是克服血管化不良肿瘤中药物蓄积不足的一种有前景的策略。
