通过利用肿瘤微环境增强抗癌治疗的纳米颗粒设计策略。
Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.
作者信息
Dai Yunlu, Xu Can, Sun Xiaolian, Chen Xiaoyuan
机构信息
Centre for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang'an South Road, Xiamen 361102, China.
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Chem Soc Rev. 2017 Jun 21;46(12):3830-3852. doi: 10.1039/c6cs00592f. Epub 2017 May 18.
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells, including tumour cells, macrophages, immune and fibroblast cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in detail. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.
纳米载体能够有效地将抗癌药物输送到肿瘤部位。与正常组织相比，肿瘤微环境具有一些独特的特性，如血管异常、缺氧和酸性pH值。实体瘤中存在多种类型的细胞，包括肿瘤细胞、巨噬细胞、免疫细胞和成纤维细胞，由有缺陷的血管供血。利用肿瘤微环境有助于设计纳米颗粒以提高治疗效果。在这篇综述文章中，我们总结了各种用于癌症治疗的纳米制剂的最新进展，特别强调了对肿瘤微环境刺激有响应的制剂。还突出了许多具有有望的癌症治疗效果的肿瘤微环境调节策略。还详细讨论了设计考虑方面的未来挑战和机遇。我们相信，这些肿瘤微环境调节策略为纳米颗粒配方实际转化为临床应用提供了很好的机会。
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