Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Department of Gynecology, Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Front Endocrinol (Lausanne). 2021 Mar 8;12:633766. doi: 10.3389/fendo.2021.633766. eCollection 2021.
To evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.
The study included 2011 women who underwent fertilization/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.
Higher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21-2.08], quartile 3 OR 1.36 [1.04-1.77]), LDL-C (quartile 1 OR 1.41 [1.07-1.86]), and TG (quartile 2 OR 1.39 [1.06-1.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58-3.13], quartile 2 OR 1.78 [1.27-2.50], quartile 3 OR 1.51 [1.07-2.13]), TC (quartile 1 OR 1.39 [1.00-1.93]), TG (quartile 1 OR 1.44 [1.03-2.03], quartile 2 OR 1.46 [1.04-2.04], quartile 3 OR 1.44 [1.04-1.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51-0.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30-0.66], quartile 2 OR 0.49 [0.33-0.73], quartile 3 OR 0.63 [0.43-0.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07-2.39]) were independently associated with miscarriage.
Serum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.
评估血清脂质水平与接受辅助生殖的女性治疗结局之间的关系。
该研究纳入了 2011 名接受新鲜胚胎移植的体外受精/卵胞浆内单精子注射的女性。血清脂质评估包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）。卵巢刺激结局包括子宫内膜厚度和获取的卵母细胞数量，生殖结局包括活产、临床妊娠和流产。
较高的 HDL-C 四分位间距与更多的卵母细胞获取有关。在调整了潜在混杂因素后，TC（四分位 1 比值比 [OR] 1.59 [1.21-2.08]，四分位 3 OR 1.36 [1.04-1.77]）、LDL-C（四分位 1 OR 1.41 [1.07-1.86]）和 TG（四分位 2 OR 1.39 [1.06-1.84]）与临床妊娠独立相关。较低的 LDL-C（四分位 1 OR 2.22 [1.58-3.13]，四分位 2 OR 1.78 [1.27-2.50]，四分位 3 OR 1.51 [1.07-2.13]）、TC（四分位 1 OR 1.39 [1.00-1.93]）、TG（四分位 1 OR 1.44 [1.03-2.03]，四分位 2 OR 1.46 [1.04-2.04]，四分位 3 OR 1.44 [1.04-1.99]）和较高的 HDL-C（四分位 2 OR 0.71 [0.51-0.99]）与活产独立相关。较高的 LDL-C（四分位 1 OR 0.44 [0.30-0.66]，四分位 2 OR 0.49 [0.33-0.73]，四分位 3 OR 0.63 [0.43-0.94]）和较低的 HDL-C（四分位 1 OR 1.60 [1.07-2.39]）与流产独立相关。
血清脂质水平与接受辅助生殖的女性的治疗结局有关。
