血清脂质水平与接受辅助生殖治疗的女性的治疗结局：一项回顾性队列研究。
Serum Lipid Levels and Treatment Outcomes in Women Undergoing Assisted Reproduction: A Retrospective Cohort Study.
机构信息
Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Department of Gynecology, Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2021 Mar 8;12:633766. doi: 10.3389/fendo.2021.633766. eCollection 2021.
OBJECTIVE
To evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.
MATERIALS AND METHODS
The study included 2011 women who underwent fertilization/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.
RESULTS
Higher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21-2.08], quartile 3 OR 1.36 [1.04-1.77]), LDL-C (quartile 1 OR 1.41 [1.07-1.86]), and TG (quartile 2 OR 1.39 [1.06-1.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58-3.13], quartile 2 OR 1.78 [1.27-2.50], quartile 3 OR 1.51 [1.07-2.13]), TC (quartile 1 OR 1.39 [1.00-1.93]), TG (quartile 1 OR 1.44 [1.03-2.03], quartile 2 OR 1.46 [1.04-2.04], quartile 3 OR 1.44 [1.04-1.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51-0.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30-0.66], quartile 2 OR 0.49 [0.33-0.73], quartile 3 OR 0.63 [0.43-0.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07-2.39]) were independently associated with miscarriage.
CONCLUSIONS
Serum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.
目的
评估血清脂质水平与接受辅助生殖的女性治疗结局之间的关系。
材料与方法
该研究纳入了 2011 名接受新鲜胚胎移植的体外受精/卵胞浆内单精子注射的女性。血清脂质评估包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）。卵巢刺激结局包括子宫内膜厚度和获取的卵母细胞数量，生殖结局包括活产、临床妊娠和流产。
结果
较高的 HDL-C 四分位间距与更多的卵母细胞获取有关。在调整了潜在混杂因素后，TC（四分位 1 比值比 [OR] 1.59 [1.21-2.08]，四分位 3 OR 1.36 [1.04-1.77]）、LDL-C（四分位 1 OR 1.41 [1.07-1.86]）和 TG（四分位 2 OR 1.39 [1.06-1.84]）与临床妊娠独立相关。较低的 LDL-C（四分位 1 OR 2.22 [1.58-3.13]，四分位 2 OR 1.78 [1.27-2.50]，四分位 3 OR 1.51 [1.07-2.13]）、TC（四分位 1 OR 1.39 [1.00-1.93]）、TG（四分位 1 OR 1.44 [1.03-2.03]，四分位 2 OR 1.46 [1.04-2.04]，四分位 3 OR 1.44 [1.04-1.99]）和较高的 HDL-C（四分位 2 OR 0.71 [0.51-0.99]）与活产独立相关。较高的 LDL-C（四分位 1 OR 0.44 [0.30-0.66]，四分位 2 OR 0.49 [0.33-0.73]，四分位 3 OR 0.63 [0.43-0.94]）和较低的 HDL-C（四分位 1 OR 1.60 [1.07-2.39]）与流产独立相关。
结论
血清脂质水平与接受辅助生殖的女性的治疗结局有关。
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