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冻融胚胎移植:成功的子宫内膜准备的循证标志物。

Frozen embryo transfer: evidence-based markers for successful endometrial preparation.

机构信息

Division of Reproductive Sciences, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System; and TRIO Fertility, Toronto, Ontario, Canada.

出版信息

Fertil Steril. 2020 Feb;113(2):248-251. doi: 10.1016/j.fertnstert.2019.12.008.

DOI:10.1016/j.fertnstert.2019.12.008
PMID:32106971
Abstract

Endometrial receptivity appears to be as important as chromosomal normality in determining embryo implantation and pregnancy outcome, because the ongoing pregnancy rate with transfer of preimplantation genetic testing for aneuploidy euploid blastocysts is ∼50%. This Views and Reviews article focuses on our current knowledge of the biology of endometrial receptivity and on the role of both invasive (endometrial biopsy) and noninvasive (ultrasound) assessment in successful endometrial preparation for frozen-thawed embryo transfer.

摘要

子宫内膜容受性似乎与染色体正常性一样重要,决定胚胎着床和妊娠结局,因为移植非整倍体胚胎的种植率约为 50%。这篇观点和综述文章主要关注我们目前对子宫内膜容受性生物学的认识,以及侵袭性(子宫内膜活检)和非侵袭性(超声)评估在冷冻胚胎解冻移植中成功准备子宫内膜的作用。

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Frozen embryo transfer: evidence-based markers for successful endometrial preparation.冻融胚胎移植:成功的子宫内膜准备的循证标志物。
Fertil Steril. 2020 Feb;113(2):248-251. doi: 10.1016/j.fertnstert.2019.12.008.
2
Correlation between plasmatic progesterone, endometrial receptivity genetic assay and implantation rates in frozen-thawed transferred euploid embryos. A multivariate analysis.冻融胚胎移植中胚胎整倍体、孕激素和子宫内膜容受性基因检测与种植率的相关性:多因素分析。
Eur J Obstet Gynecol Reprod Biol. 2021 Aug;263:192-197. doi: 10.1016/j.ejogrb.2021.05.047. Epub 2021 Jun 9.
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Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support.冻融胚胎移植周期的最佳子宫内膜准备:着床窗与孕激素支持
Fertil Steril. 2016 Apr;105(4):867-72. doi: 10.1016/j.fertnstert.2016.01.006. Epub 2016 Jan 25.
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[Pregnancy outcome of frozen-thawed embryo transfers in different endometrial progesterone preparation time].[不同子宫内膜孕激素准备时间的冻融胚胎移植的妊娠结局]
Zhonghua Fu Chan Ke Za Zhi. 2014 Jun;49(6):424-7.
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Does the endometrial receptivity array really provide personalized embryo transfer?子宫内膜容受性 array 真的能提供个性化的胚胎移植吗?
J Assist Reprod Genet. 2018 Jul;35(7):1301-1305. doi: 10.1007/s10815-018-1190-9. Epub 2018 May 8.
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Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers.孕激素作用下的子宫内膜致密化(厚度减小)可使冻融胚胎移植获得最佳妊娠结局。
Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.
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Endometrial Receptivity Analysis - a tool to increase an implantation rate in assisted reproduction.子宫内膜容受性分析——一种提高辅助生殖中着床率的工具。
Ceska Gynekol. 2019 Spring;84(3):177-183.
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[Relationship between endometrial thickness and pregnancy outcomes based on frozen-thawed embryo transfer cycles].基于冻融胚胎移植周期的子宫内膜厚度与妊娠结局的关系
Zhonghua Fu Chan Ke Za Zhi. 2018 Nov 25;53(11):742-748. doi: 10.3760/cma.j.issn.0529-567x.2018.11.003.
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One center experience with a personalized frozen-thawed embryo transfer in patients with recurrent implantation failure.一个中心在反复着床失败患者中应用个体化冻融胚胎移植的经验。
J Assist Reprod Genet. 2023 Jul;40(7):1639-1647. doi: 10.1007/s10815-023-02835-7. Epub 2023 Jun 1.
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Hormonal induction of endometrial receptivity.激素诱导子宫内膜容受性。
Fertil Steril. 2011 Sep;96(3):530-5. doi: 10.1016/j.fertnstert.2011.07.1097.

引用本文的文献

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Clinical pregnancy outcomes in young women with diminished ovarian reserve undergoing frozen embryo transfer: a comprehensive analysis with exploratory insights into endometrial aging.卵巢储备功能减退的年轻女性行冷冻胚胎移植后的临床妊娠结局:对子宫内膜老化的综合分析及探索性见解
Front Endocrinol (Lausanne). 2025 Jul 29;16:1608200. doi: 10.3389/fendo.2025.1608200. eCollection 2025.
2
Age does not affect maximal endometrial thickness achieved in frozen embryo transfer cycles: a SARTCORS study.年龄不影响冷冻胚胎移植周期中所达到的最大子宫内膜厚度:一项美国生殖医学学会辅助生殖技术委员会报告系统(SART CORS)的研究
Reprod Biol Endocrinol. 2025 Aug 2;23(1):115. doi: 10.1186/s12958-025-01451-7.
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Endometrial compaction can improve assisted reproductive technology outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy: A cross-sectional study.
子宫内膜致密化可改善采用激素替代疗法的冻融胚胎移植周期中的辅助生殖技术结局:一项横断面研究。
Int J Reprod Biomed. 2025 May 1;23(2):141-152. doi: 10.18502/ijrm.v23i2.18484. eCollection 2024 May.
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Effects of vaginal vs oral progesterone supplementation before embryo transfer on live birth rates and levels: a randomized trial.胚胎移植前阴道与口服补充孕酮对活产率及水平的影响:一项随机试验。
Reprod Fertil. 2025 Mar 20;6(1). doi: 10.1530/RAF-24-0094. Print 2025 Jan 1.
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Gonadotropin Releasing Hormone Agonists Combined with Hormone Replacement Therapy Significantly Improves Reproductive Outcomes for Patients with Thin Endometrium and Intramural Fibroids in Frozen Embryo Transfer Cycles.促性腺激素释放激素激动剂联合激素替代疗法显著改善冻融胚胎移植周期中子宫内膜薄和壁间肌瘤患者的生殖结局。
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J Ultrasound Med. 2025 Apr;44(4):655-666. doi: 10.1002/jum.16625. Epub 2024 Nov 29.
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