Fourth Affiliated Hospital, Zhejiang University School of Medicine, No. 1 Shang Cheng Avenue, Yiwu, 322000, Zhejiang, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
J Ovarian Res. 2022 Sep 30;15(1):109. doi: 10.1186/s13048-022-01041-w.
This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning.
A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6 of July 2021 that compared the metabolic profile of POI women with a healthy control group were assessed. Mean differences (MD) and 95% confidence interval (CI) were pooled using the fixed or random effect models.
A total of 21 studies involving 1573 women with POI and 1762 control women were included. POI patients presented significantly higher waist circumference, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and fasting glucose. Additionally, POI patients had marginally higher insulin level. However, the differences in systolic, and diastolic blood pressure were non-significant relative to the control group.
POI is associated with alterations in certain metabolic parameters compared to control women. This finding highlights the importance of early screening and the lifelong management of metabolic health for women with POI.
本综述旨在研究与卵巢功能正常的女性相比，卵巢早衰（POI）女性的代谢特征。
系统检索 PubMed、EMBASE 和 Web of Science 中截至 2021 年 7 月 6 日发表的比较 POI 女性与健康对照组代谢特征的观察性研究。使用固定或随机效应模型汇总平均差异（MD）和 95%置信区间（CI）。
共纳入 21 项研究，涉及 1573 名 POI 患者和 1762 名对照女性。POI 患者的腰围、总胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三酯和空腹血糖明显更高。此外，POI 患者的胰岛素水平略高。然而，与对照组相比，收缩压和舒张压的差异无统计学意义。
与对照组女性相比，POI 与某些代谢参数的改变有关。这一发现强调了对 POI 女性进行早期筛查和终身代谢健康管理的重要性。
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