Wegener T, Sandhagen B, Chan K W, Saldeen T
Department of Lung Medicine, Uppsala University, Sweden.
Ups J Med Sci. 1988;93(1):81-9. doi: 10.1517/03009734000000041.
The therapeutic effect of N-acetylcysteine (NAC) in paraquat-treated rats was investigated. The animals were divided into four groups: A = control; B = NAC; C = paraquat; D = NAC + paraquat. In the appropriate groups, paraquat 20 mg/kg body weight was administered intraperitoneally and 1% NAC solution was provided as drinking water. All surviving rats were killed on the seventh day after paraquat exposure. The lungs were graded histologically on the basis of oedema and cellular infiltration. On histological examination, the lungs of poisoned rats that had received NAC displayed a tendency towards less oedema and cellular infiltration than those of poisoned rats not treated with NAC. It is concluded that NAC might afford some therapeutic effect against paraquat toxicity in rats.
研究了N-乙酰半胱氨酸（NAC）对百草枯处理大鼠的治疗效果。将动物分为四组：A = 对照组；B = NAC组；C = 百草枯组；D = NAC + 百草枯组。在相应组中，腹腔注射20 mg/kg体重的百草枯，并提供1%的NAC溶液作为饮用水。在百草枯暴露后第七天处死所有存活的大鼠。根据水肿和细胞浸润情况对肺组织进行组织学分级。组织学检查显示，接受NAC的中毒大鼠的肺组织水肿和细胞浸润程度比未接受NAC治疗的中毒大鼠轻。结论是NAC可能对大鼠百草枯中毒具有一定的治疗作用。
