Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203/8, 500 05, Hradec Králové, Czech Republic.
Department of Clinical Pharmacy, Hospital Pharmacy, University Hospital Hradec Králové, Hradec Králové, Czech Republic.
Int J Clin Pharm. 2021 Oct;43(5):1218-1226. doi: 10.1007/s11096-021-01237-y. Epub 2021 Mar 24.
Background Geriatric patients represent a vulnerable population in terms of adverse drug events (ADEs). Objective The aims of this study were to determine the prevalence and preventability of hospital admissions to a geriatric ward related to ADEs, to identify medications involved in these ADEs and to describe potential preventability aspects of ADE-related admissions. Setting University Hospital Hradec Králové, Czech Republic. Methods This cross-sectional study evaluated acute hospital admissions to the geriatric ward of University Hospital Hradec Králové over a period of nine months (April-December 2017). Medication reviews were performed in order to identify ADE-related hospital admissions. Causality was assessed using the World Health Organization-Uppsala Monitoring Centre criteria. Modified Schumock-Thornton algorithm was used to assess the preventability of ADEs. Main outcome measure 9-month-prevalence of ADE-related hospital admissions. Results A total of 366 hospital admissions were included. The 9-month-prevalence of ADE-related hospital admissions was 11.75% [95% confidence interval 8.45-15.05]. Antithrombotic agents and diuretics represented the most common medication classes associated with ADEs (30.2% each). Electrolyte disturbances and gastrointestinal haemorrhages and ulcerations were the most frequently observed ADEs associated with hospital admission. Out of 43 ADE-related hospitalisations, 23 (53.5%) were considered potentially preventable. Conclusion The contribution of ADEs to hospital admission to the geriatric ward was not negligible. Our results also suggest that 53.5% of identified ADE-related admissions could be potentially prevented. This finding demonstrates just how important the research on the preventability of medication-related hospitalisations is. Further studies and implementations are still needed aiming to minimize the risk of medication-related harm.
老年患者在药物不良事件（ADE）方面属于弱势群体。
本研究旨在确定与 ADE 相关的老年病房住院的患病率和可预防率，确定这些 ADE 涉及的药物，并描述与 ADE 相关的住院的潜在可预防方面。
捷克共和国赫拉德茨-克拉洛韦大学医院。
本横断面研究评估了赫拉德茨-克拉洛韦大学医院老年病房在九个月期间（2017 年 4 月至 12 月）的急性住院情况。进行药物审查以确定与 ADE 相关的住院情况。使用世界卫生组织-乌普萨拉监测中心标准评估因果关系。使用改良 Schumock-Thornton 算法评估 ADE 的可预防程度。
与 ADE 相关的住院 9 个月的患病率。
共纳入 366 例住院患者。与 ADE 相关的住院 9 个月的患病率为 11.75%[95%置信区间 8.45-15.05]。抗血栓形成剂和利尿剂是与 ADE 最常见的药物类别（各占 30.2%）。电解质紊乱以及胃肠道出血和溃疡是与住院相关的最常见 ADE。在 43 例与 ADE 相关的住院治疗中，有 23 例（53.5%）被认为是潜在可预防的。
ADE 对老年病房住院的贡献不可忽视。我们的结果还表明，53.5%的确定与 ADE 相关的住院治疗可以潜在预防。这一发现表明，对与药物相关的住院治疗的可预防性进行研究非常重要。仍需要进一步的研究和实施，以尽量减少与药物相关的伤害风险。
