压力下的眶额皮质。
The stressed orbitofrontal cortex.
机构信息
Graduate Training Program in Neuroscience.
出版信息
Behav Neurosci. 2021 Apr;135(2):202-209. doi: 10.1037/bne0000456. Epub 2021 Mar 25.
Abstract
Stressor exposure causes dendritic remodeling on excitatory neurons in multiple regions of the brain, including the orbitofrontal cortex (OFC). Additionally, stressor and exogenous stress hormone exposure impair cognitive functions that are dependent on the OFC. For this Special Issue on the OFC, we summarize current literature regarding how stress-prenatal, postnatal, and even inter-generational-affects OFC neuron structure in rodents. We discuss dendrite structure, dendritic spines, and gene expression. We aim to provide a focused resource for those interested in how stressors impact this heterogeneous brain region. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
摘要
应激源暴露会导致大脑多个区域（包括眶额皮层[OFC]）的兴奋性神经元发生树突重塑。此外，应激源和外源性应激激素暴露会损害依赖 OFC 的认知功能。本期关于 OFC 的特刊总结了目前关于应激源如何影响啮齿动物 OFC 神经元结构的文献，包括产前、产后甚至代际应激。我们讨论了树突结构、树突棘和基因表达。我们旨在为那些有兴趣了解应激源如何影响这个异质脑区的人提供一个重点资源。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
相似文献
1
The stressed orbitofrontal cortex.
Behav Neurosci. 2021 Apr;135(2):202-209. doi: 10.1037/bne0000456. Epub 2021 Mar 25.
2
Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy.
Eur J Neurosci. 2006 Sep;24(5):1477-87. doi: 10.1111/j.1460-9568.2006.05024.x. Epub 2006 Sep 8.
3
Piecing together the orbitofrontal puzzle.
Behav Neurosci. 2021 Apr;135(2):301-311. doi: 10.1037/bne0000466.
4
To be specific: The role of orbitofrontal cortex in signaling reward identity.
Behav Neurosci. 2021 Apr;135(2):210-217. doi: 10.1037/bne0000455. Epub 2021 Mar 18.
5
Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.
J Neurosci. 2019 Jun 5;39(23):4595-4605. doi: 10.1523/JNEUROSCI.2031-18.2019. Epub 2019 Apr 2.
6
The orbitofrontal cortex in temporal cognition.
Behav Neurosci. 2021 Apr;135(2):154-164. doi: 10.1037/bne0000430.
7
Does disrupting the orbitofrontal cortex alter sensitivity to punishment? A potential mechanism of compulsivity.
Behav Neurosci. 2021 Apr;135(2):174-181. doi: 10.1037/bne0000443.
8
Heterogeneous value coding in orbitofrontal populations.
Behav Neurosci. 2021 Apr;135(2):245-254. doi: 10.1037/bne0000457.
9
Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7.
Neuropharmacology. 2016 Oct;109:7-17. doi: 10.1016/j.neuropharm.2016.02.020. Epub 2016 Feb 24.
10
The rodent lateral orbitofrontal cortex as an arbitrator selecting between model-based and model-free learning systems.
Behav Neurosci. 2021 Apr;135(2):226-244. doi: 10.1037/bne0000454.
引用本文的文献
1
Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity.
Sci Rep. 2025 Jul 17;15(1):25934. doi: 10.1038/s41598-025-11208-2.
2
Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression.
J Affect Disord. 2024 Dec 15;367:307-317. doi: 10.1016/j.jad.2024.08.148. Epub 2024 Aug 25.
3
Cocaine disrupts action flexibility via glucocorticoid receptors.
iScience. 2024 May 28;27(7):110148. doi: 10.1016/j.isci.2024.110148. eCollection 2024 Jul 19.
4
Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.
Mol Psychiatry. 2024 Sep;29(9):2787-2798. doi: 10.1038/s41380-024-02540-6. Epub 2024 Apr 5.
5
Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors.
Eur Arch Psychiatry Clin Neurosci. 2024 Dec;274(8):1911-1922. doi: 10.1007/s00406-023-01741-4. Epub 2024 Feb 6.
6
Recruitment of Corticotropin-Releasing Hormone (CRH) Neurons in Categorically Distinct Stress Reactions in the Mouse Brain.
Int J Mol Sci. 2023 Jul 21;24(14):11736. doi: 10.3390/ijms241411736.
本文引用的文献
1
Optogenetically-induced long term depression in the rat orbitofrontal cortex ameliorates stress-induced reversal learning impairment.
Neurobiol Stress. 2020 Oct 24;13:100258. doi: 10.1016/j.ynstr.2020.100258. eCollection 2020 Nov.
2
Morphological Responses of Excitatory Prelimbic and Orbitofrontal Cortical Neurons to Excess Corticosterone in Adolescence and Acute Stress in Adulthood.
Front Neuroanat. 2020 Sep 8;14:45. doi: 10.3389/fnana.2020.00045. eCollection 2020.
3
Social and olfactory experiences modify neuronal morphology of orbital frontal cortex.
Behav Neurosci. 2020 Feb;134(1):59-68. doi: 10.1037/bne0000350.
4
Social Isolation in Adolescence Disrupts Cortical Development and Goal-Dependent Decision-Making in Adulthood, Despite Social Reintegration.
eNeuro. 2019 Sep 23;6(5). doi: 10.1523/ENEURO.0318-19.2019. Print 2019 Sep/Oct.
5
Glucocorticoid-sensitive ventral hippocampal-orbitofrontal cortical connections support goal-directed action - Curt Richter Award Paper 2019.
Psychoneuroendocrinology. 2019 Dec;110:104436. doi: 10.1016/j.psyneuen.2019.104436. Epub 2019 Sep 6.
6
β1-Integrins in the Developing Orbitofrontal Cortex Are Necessary for Expectancy Updating in Mice.
J Neurosci. 2019 Aug 21;39(34):6644-6655. doi: 10.1523/JNEUROSCI.3072-18.2019. Epub 2019 Jun 28.
7
Ancestral Stress Alters Lifetime Mental Health Trajectories and Cortical Neuromorphology via Epigenetic Regulation.
Sci Rep. 2019 Apr 23;9(1):6389. doi: 10.1038/s41598-019-42691-z.
8
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.
Science. 2019 Apr 12;364(6436). doi: 10.1126/science.aat8078.
9
Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.
J Neurosci. 2019 Jun 5;39(23):4595-4605. doi: 10.1523/JNEUROSCI.2031-18.2019. Epub 2019 Apr 2.
10
Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts.
Neurosci Biobehav Rev. 2018 Dec;95:535-558. doi: 10.1016/j.neubiorev.2018.10.015.
Zotero 插件