压力下的眶额皮质。
The stressed orbitofrontal cortex.
机构信息
Graduate Training Program in Neuroscience.
出版信息
Behav Neurosci. 2021 Apr;135(2):202-209. doi: 10.1037/bne0000456. Epub 2021 Mar 25.
Abstract
Stressor exposure causes dendritic remodeling on excitatory neurons in multiple regions of the brain, including the orbitofrontal cortex (OFC). Additionally, stressor and exogenous stress hormone exposure impair cognitive functions that are dependent on the OFC. For this Special Issue on the OFC, we summarize current literature regarding how stress-prenatal, postnatal, and even inter-generational-affects OFC neuron structure in rodents. We discuss dendrite structure, dendritic spines, and gene expression. We aim to provide a focused resource for those interested in how stressors impact this heterogeneous brain region. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
摘要
应激源暴露会导致大脑多个区域（包括眶额皮层[OFC]）的兴奋性神经元发生树突重塑。此外，应激源和外源性应激激素暴露会损害依赖 OFC 的认知功能。本期关于 OFC 的特刊总结了目前关于应激源如何影响啮齿动物 OFC 神经元结构的文献，包括产前、产后甚至代际应激。我们讨论了树突结构、树突棘和基因表达。我们旨在为那些有兴趣了解应激源如何影响这个异质脑区的人提供一个重点资源。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
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