Department of Behavioral Science.
Department of Psychiatry.
Exp Clin Psychopharmacol. 2022 Apr;30(2):194-208. doi: 10.1037/pha0000406. Epub 2021 Mar 25.
Recent advances in diagnostic research identified that individuals with higher impulsivity and sensation-seeking scores tend to report more positive subjective responses to stimulant drugs such as amphetamine. The current exploratory study hypothesized that differences in underlying mesocorticolimbic circuitry may mediate the relationship between personality and responses to stimulants due to its previously established implication in reward processes as well as the overlap between its dopaminergic projections and the pharmacodynamics of many stimulants. Forty participants (20 female) were recruited with relatively high- and low-impulsivity and sensation-seeking scores as defined by the Zuckerman-Kuhlman Personality Questionnaire (Form IIIR; Zuckerman, Kuhlman, Joireman, Teta, & Kraft, 1993) for a double-blind, placebo-controlled, intranasal amphetamine administration study conducted within an MRI scanner. Active state seed-to-voxel connectivity analyses assessed the effects of amphetamine, personality, subjective responses to amphetamine, and their interactions with mesocorticolimbic seeds on data collected during monetary incentive delay and go/no-go task performance. Results indicated that amphetamine administration largely disrupted brain activity as evidenced by connectivity values shifting toward no correlation among brain stem, striatal, and frontal cortex regions. Additionally, associations of impulsivity and connectivity between ventral tegmental and medial orbitofrontal as well as lateral orbitofrontal and putamen regions were inverted from negative to positive during the placebo and amphetamine conditions, respectively. Personality was unrelated to subjective responses to amphetamine. Results are interpreted as providing evidence of underlying differences in mesocorticolimbic circuitry being a potential target for requisite diagnostic and treatment strategies implicated with stimulant use disorders, but further research is needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
最近的诊断研究进展表明，冲动性和寻求刺激得分较高的个体往往会报告对安非他命等兴奋剂有更积极的主观反应。本探索性研究假设，由于中脑边缘多巴胺系统在奖励过程中的先前确立的作用以及其多巴胺能投射与许多兴奋剂的药效学之间的重叠，潜在的中脑边缘多巴胺系统回路的差异可能会调节人格与兴奋剂反应之间的关系。40 名参与者（20 名女性）根据 Zuckerman-Kuhlman 人格问卷（第三版修订版；Zuckerman、Kuhlman、Joireman、Teta 和 Kraft，1993）中的高和低冲动性和寻求刺激得分被招募进来，进行了一项双盲、安慰剂对照、鼻内安非他命给药研究，该研究在 MRI 扫描仪内进行。主动状态种子到体素连接分析评估了安非他命、人格、对安非他命的主观反应以及它们与中脑边缘多巴胺系统种子的相互作用对在金钱奖励延迟和 Go/No-Go 任务表现期间收集的数据的影响。结果表明，安非他命给药在很大程度上扰乱了大脑活动，表现为脑干、纹状体和额叶区域之间的连接值向无相关性转移。此外，冲动性和腹侧被盖区与内侧眶额回以及外侧眶额回与壳核之间的连接在安慰剂和安非他命条件下分别从负相关变为正相关。人格与对安非他命的主观反应无关。结果表明，中脑边缘多巴胺系统回路的潜在差异是与兴奋剂使用障碍相关的必要诊断和治疗策略的潜在靶点，但需要进一步研究。（PsycInfo 数据库记录（c）2022 APA，保留所有权利）。
