Laboratory of Molecular & Cellular Cardiology, Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, J. B. Winsløws Vej 25, Odense C 5000, Denmark.
The Danish Regenerative Center, Odense University Hospital, J. B. Winsløws Vej 4, Odense C 5000, Denmark.
Regen Med. 2021 Feb;16(2):117-130. doi: 10.2217/rme-2020-0171. Epub 2021 Mar 25.
Polycaprolactone (PCL) scaffolds exhibit high biocompatibility and are attractive as vascular conduits. PCL tubes were cultivated in bioreactor with human adipose regenerative cells to assess cytocompatibility, whereas PCL tube patency was evaluated in sheep carotid bypass with and without antithrombotic treatment. results revealed increasing adipose regenerative cells on PCL using dynamic bioreactor culturing. data showed that 67% (2/3) of grafts in the antithrombotic group were patent at day 28, while 100% (3/3) of control grafts were occluded already during the first week due to thrombosis. Histology showed that patent PCL grafts were recellularized by host cells. PCL tubes may work as small diameter vascular scaffolds under antithrombotic treatment.
聚己内酯（PCL）支架具有良好的生物相容性，可用作血管移植物。我们将人脂肪再生细胞在生物反应器中培养在 PCL 管上，以评估其细胞相容性，同时在有和没有抗血栓治疗的绵羊颈动脉旁路模型中评估 PCL 管的通畅性。结果显示，使用动态生物反应器培养，PCL 上的脂肪再生细胞数量增加。数据显示，在抗血栓治疗组中，67%（2/3）的移植物在第 28 天通畅，而对照组的 100%（3/3）的移植物在第一周就因血栓形成而闭塞。组织学显示，通畅的 PCL 移植物被宿主细胞再内皮化。在抗血栓治疗下，PCL 管可作为小直径血管支架。
