Laboratory of Phytochemistry - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil.
Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo - UNIFESP, Diadema, SP, Brazil.
Nat Prod Res. 2022 Mar;36(6):1641-1647. doi: 10.1080/14786419.2021.1895151. Epub 2021 Mar 25.
Mart. popularly known as 'Cangussu-branco', is used in Brazilian folk medicine to treat inflammations and infections. This work aimed to carry out phytochemical analysis and evaluate the anti-inflammatory potential of . In the phytochemical investigation, in addition to the presence of two ecdysteroids, 20 R-dihydroxyecdysone and 20-hydroxyecdysone, identified by HPLC-PDA-MS and NMR, 22 compounds were identified by GC-MS. In the cytotoxicity study, the aqueous extract of the roots of this species did not show in vitro toxicity of PBMCs in the concentrations of 250, 500 and 1000 µg/mL when analyzed by the trypan blue exclusion method. Also, it was effective in reducing lymphocyte proliferation, stimulated with the mitogen PHA, by 26.02%, 48.57% and 50.49% when compared to dexamethasone, respectively. In this work we present information about the phytochemicals of , showing that the species is promising in obtaining compounds with medicinal potential mainly anti-inflammatory potential.
马黛，俗称“Cangussu-branco”，在巴西民间医学中用于治疗炎症和感染。本工作旨在进行植物化学分析并评估 的抗炎潜力。在植物化学研究中，除了通过 HPLC-PDA-MS 和 NMR 鉴定出两种蜕皮甾体，20-羟基蜕皮甾酮和 20-羟蜕皮甾酮外，还通过 GC-MS 鉴定出 22 种化合物。在细胞毒性研究中，通过台盼蓝排除法分析，在浓度为 250、500 和 1000μg/mL 时，该植物根的水提取物对 PBMCs 没有显示出体外毒性。此外，与地塞米松相比，它分别有效抑制有丝分裂原 PHA 刺激的淋巴细胞增殖 26.02%、48.57%和 50.49%。在这项工作中，我们提供了关于 的植物化学信息，表明该物种在获得具有药用潜力的化合物方面具有很大的前景，主要是抗炎潜力。
