Feil W, Wenzl E, Vattay P, Starlinger M, Schiessel R
I. Chirurgische Universitätsklinik, Wien.
Wien Klin Wochenschr. 1988 Mar 18;100(6):173-82.
Epithelial repair after luminal acid exposure was studied in the rabbit duodenum in vivo, HCl (200 mM for 30 min) caused uniform damage of the mucosa confined to the villi, 50% of the total villus height was affected by the acid-induced lesion in the proximal, and 70% in the distal duodenum. After demarcation and detachment of the necrotic tissue the defect was bridged by the remaining viable epithelial cells underneath a layer of mucus and necrotic debris (= necrotic layer). Mucosal repair resulted in a reduction of villus height by 62% in the proximal, and 77% in the distal duodenum. This process of mucosal repair progressed continuously, so that 9 hours after acid damage only 33% of villi in the proximal, and 41% in the distal duodenum were not yet fully restored, irrespective of luminal pH(pHL = 7 or pHL = 3). The difference between proximal and distal duodenum is due to the higher acid susceptibility of the distal duodenum. Rapid epithelial repair of the duodenal mucosa in vivo provides an important protective mechanism against the aggression from luminal acid.
在体内对兔十二指肠腔内酸暴露后的上皮修复进行了研究，盐酸（200 mM，30分钟）导致局限于绒毛的黏膜均匀损伤，十二指肠近端酸诱导损伤影响了总绒毛高度的50%，远端为70%。坏死组织分界和脱离后，缺损由一层黏液和坏死碎片（=坏死层）下剩余的存活上皮细胞桥接。黏膜修复使十二指肠近端绒毛高度降低62%，远端降低77%。黏膜修复过程持续进行，因此酸损伤9小时后，无论腔内pH值（pHL = 7或pHL = 3）如何，十二指肠近端只有33%的绒毛、远端只有41%的绒毛尚未完全恢复。十二指肠近端和远端的差异是由于远端十二指肠对酸的敏感性更高。十二指肠黏膜在体内的快速上皮修复提供了一种重要的保护机制，以抵御腔内酸的侵袭。
