One-Pot Synthesis of -Iodo Sulfoximines from Sulfides.

This is the first report on the synthesis and characterization of -iodo sulfoximines. The synthesis was designed as a room temperature one-pot cascade reaction from readily available sulfides as starting compounds, converted into sulfoximines by reaction with ammonium carbonate and (diacetoxyiodo)benzene, followed by iodination with -iodosuccinimide or iodine , in up to 90% isolated yields, also at a multigram scale. Iodination of aryls with -iodo sulfoximines, oxidation, and conversion to -SCF congeners have been demonstrated.