无活化 C(sp3)-H 键的硼化反应：溴化物作为无痕迹导向基团。
Borylation of Unactivated C(sp)-H Bonds with Bromide as a Traceless Directing Group.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.
The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Org Lett. 2021 Apr 16;23(8):2948-2953. doi: 10.1021/acs.orglett.1c00617. Epub 2021 Mar 25.
A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.
本文描述了一种钯催化的带有溴化物作为无痕迹导向基团的烷基 C-H 硼化反应，为具有β-全碳季立体中心的烷基硼酸酯的合成提供了一种方便的方法。该方法具有广泛的底物范围、优异的位点选择性和良好的官能团容忍性。
Zotero 插件