Department of Speech-Language Pathology, Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Rehabilitation Sciences Institute, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
J Autism Dev Disord. 2022 Feb;52(2):725-737. doi: 10.1007/s10803-021-04975-0. Epub 2021 Mar 25.
Examining brain and behaviour associations for language in autism spectrum disorder (ASD) may bring us closer to identifying neural profiles that are unique to a subgroup of individuals with ASD identified as language impaired (e.g. ASD LI+). We conducted a scoping review to examine brain regions that are associated with language performance in ASD. Further, we examined methodological differences across studies in how language ability was characterized and what neuroimaging methods were used to explore brain regions. Seventeen studies met inclusion criteria. Brain regions specific to ASD LI+ groups were found, however inconsistencies in brain and language associations were evident across study findings. Participant age, age-appropriate language scores, and neuroimaging methods likely contributed to differences in associations found.
研究自闭症谱系障碍（ASD）中的语言与大脑和行为的关联，可能有助于我们确定语言障碍（如 ASD LI+）亚组个体特有的神经特征。我们进行了一项范围综述，以研究与 ASD 中的语言表现相关的大脑区域。此外，我们还研究了研究中语言能力特征和用于探索大脑区域的神经影像学方法的方法学差异。有 17 项研究符合纳入标准。发现了特定于 ASD LI+组的大脑区域，但是研究结果表明，大脑和语言之间的关联存在不一致。参与者的年龄、适合年龄的语言分数和神经影像学方法可能导致了所发现关联的差异。
