General College of Education, Kookmin University, Seoul, South Korea.
Department of Education, Mokpo National University, Jeonnam, South Korea.
Twin Res Hum Genet. 2021 Feb;24(1):7-13. doi: 10.1017/thg.2021.5. Epub 2021 Mar 26.
The present study aimed to determine the genetic and environmental etiology of the association between childhood negative emotionality (NE) and hyperactivity/inattention problems (HIP) using South Korean elementary school twins (mean age = 10.19 years, SD = 1.79 years). Telephone interviews were given to mothers of 919 twins (229 monozygotic males: 112 pairs and 5 individuals; 148 dizygotic males: 73 pairs and 2 individuals; 180 monozygotic females: 87 pairs and 6 individuals; 103 dizygotic females: 50 pairs and 3 individuals; 259 opposite-sex dizygotic twins: 127 pairs and 5 individuals) to assess their children's NE and HIP. Consistent with prior studies, the phenotypic correlation between NE and the HIP was moderate (r = .29; 95% CI = .24, .34). Model-fitting analysis revealed that additive genetic and nonshared environmental influences on NE were .45 (95% CI [.34, .54]) and .55 (95% CI [.46, .66]), respectively, and that additive and nonadditive genetic, and nonshared environmental influences on HIP were .08 (95% CI [.03, .26]), .41 (95% CI [.21, .51]) and .51 (95% CI = .42, .61), respectively. In addition, the additive genetic correlation between NE and HIP was 1.0 (95% CI [.52, 1.00]), indicating that additive genetic factors are entirely shared between the two phenotypes. Nonadditive genetic influences were unique to HIP and not responsible for the NE-HIP association. Nonshared environmental correlation was significant but modest (re = .18, 95% CI [.06, .30]).
本研究旨在使用韩国小学双胞胎（平均年龄= 10.19 岁，SD=1.79 岁）来确定儿童负性情绪（NE）与多动/注意力不集中问题（HIP）之间关联的遗传和环境病因。对 919 对双胞胎的母亲（229 对同卵男性：112 对和 5 个个体；148 对异卵男性：73 对和 2 个个体；180 对同卵女性：87 对和 6 个个体；103 对异卵女性：50 对和 3 个个体；259 对异性异卵双胞胎：127 对和 5 个个体）进行了电话访谈，以评估他们孩子的 NE 和 HIP。与先前的研究一致，NE 和 HIP 之间的表型相关性为中等（r=.29；95%CI=.24，.34）。模型拟合分析表明，NE 的加性遗传和非共享环境影响分别为.45（95%CI [.34，.54]）和.55（95%CI [.46，.66]），而 HIP 的加性和非加性遗传、非共享环境影响分别为.08（95%CI [.03，.26]）、.41（95%CI [.21，.51]）和.51（95%CI=.42，.61）。此外，NE 和 HIP 之间的加性遗传相关性为 1.0（95%CI [.52，1.00]），表明加性遗传因素完全存在于两种表型之间。非加性遗传影响是 HIP 所特有的，与 NE-HIP 关联无关。非共享环境相关性具有显著意义但适中（re=.18，95%CI [.06，.30]）。
