Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Pharmacol Res. 2021 May;167:105570. doi: 10.1016/j.phrs.2021.105570. Epub 2021 Mar 22.
Malaria contributes to the most widespread infectious diseases worldwide. Even though current drugs are commercially available, the ever-increasing drug resistance problem by malaria parasites poses new challenges in malaria therapy. Hence, searching for efficient therapeutic strategies is of high priority in malaria control. In recent years, multi-omics technologies have been extensively applied to provide a more holistic view of functional principles and dynamics of biological mechanisms. We briefly review multi-omics technologies and focus on recent malaria progress conducted with the help of various omics methods. Then, we present up-to-date advances for multi-omics approaches in malaria. Next, we describe resistance phenomena to established antimalarial drugs and underlying mechanisms. Finally, we provide insight into novel multi-omics approaches, new drugs and vaccine developments and analyze current gaps in multi-omics research. Although multi-omics approaches have been successfully used in malaria studies, they are still limited. Many gaps need to be filled to bridge the gap between basic research and treatment of malaria patients. Multi-omics approaches will foster a better understanding of the molecular mechanisms of Plasmodium that are essential for the development of novel drugs and vaccines to fight this disastrous disease.
疟疾是全球分布最广泛的传染病之一。尽管目前有商业上可用的药物，但疟原虫不断增加的耐药性问题给疟疾治疗带来了新的挑战。因此，寻找有效的治疗策略是疟疾控制的当务之急。近年来，多组学技术已被广泛应用于提供对生物机制功能原理和动态的更全面的了解。我们简要回顾了多组学技术，并重点介绍了近年来在各种组学方法的帮助下取得的疟疾进展。然后，我们介绍了多组学方法在疟疾中的最新进展。接下来，我们描述了对现有抗疟药物的耐药现象及其潜在机制。最后，我们深入探讨了新的多组学方法、新药和疫苗的开发，并分析了多组学研究中的当前差距。尽管多组学方法已成功应用于疟疾研究，但仍有许多限制。需要填补许多空白，以弥合基础研究与疟疾患者治疗之间的差距。多组学方法将促进对疟原虫分子机制的更好理解，这对于开发新的药物和疫苗来对抗这种灾难性疾病至关重要。
