Laboratoire de Neurosciences Cognitives et Adaptatives, Université de Strasbourg, F-67000 Strasbourg, France; LNCA, UMR 7364 - CNRS, F-67000 Strasbourg, France.
Aix Marseille Université, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Neurosci Biobehav Rev. 2021 Jul;126:338-360. doi: 10.1016/j.neubiorev.2021.03.023. Epub 2021 Mar 22.
Over the past twenty years, the reuniens and rhomboid (ReRh) nuclei, which constitute the ventral midline thalamus, have received constantly growing attention. Since our first review article about the functional contributions of ReRh nuclei (Cassel et al., 2013), numerous (>80) important papers have extended anatomical knowledge, including at a developmental level, introduced new and very original electrophysiological insights on ReRh functions, and brought novel results on cognitive and non-cognitive implications of the ReRh. The current review will cover these recent articles, more on Re than on Rh, and their contribution will be approached according to their affiliation with work before 2013. These neuroanatomical, electrophysiological or behavioral findings appear coherent and point to the ReRh nuclei as two major components of a multistructural system supporting numerous cognitive (and non-cognitive) functions. They gate the flow of information, perhaps especially from the medial prefrontal cortex to the hippocampus and back, and coordinate activity and processing across these two (and possibly other) brain regions of major cognitive relevance.
在过去的二十年中，构成腹侧中线丘脑的 reunions 和菱形核（ReRh）受到了越来越多的关注。自从我们第一篇关于 ReRh 核功能贡献的综述文章（Cassel 等人，2013 年）发表以来，许多（>80）重要论文扩展了解剖学知识，包括在发育水平上，引入了关于 ReRh 功能的新的和非常原始的电生理学见解，并带来了关于 ReRh 的认知和非认知影响的新结果。当前的综述将涵盖这些最近的文章，更多的是关于 Re 而不是关于 Rh，并且根据它们与 2013 年之前的工作的联系来接近它们的贡献。这些神经解剖学、电生理学或行为学发现似乎是一致的，指出 ReRh 核是支持众多认知（和非认知）功能的多结构系统的两个主要组成部分。它们控制信息流，也许特别是从前内侧前额叶皮层到海马体再返回，协调这两个（和可能其他）主要认知相关脑区的活动和处理。
