de Mooij-van Malsen Johanne Gertrude, Röhrdanz Niels, Buschhoff Anna-Sophia, Schiffelholz Thomas, Sigurdsson Torfi, Wulff Peer
Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.
Center of Integrative Psychiatry, University Medical Center Schleswig-Holstein, Kiel, Germany.
iScience. 2023 Aug 3;26(9):107532. doi: 10.1016/j.isci.2023.107532. eCollection 2023 Sep 15.
Working memory requires maintenance of and executive control over task-relevant information on a timescale of seconds. Spatial working memory depends on interactions between hippocampus, for the representation of space, and prefrontal cortex, for executive control. A monosynaptic hippocampal projection to the prefrontal cortex has been proposed to serve this interaction. However, connectivity and inactivation experiments indicate a critical role of the nucleus reuniens in hippocampal-prefrontal communication. We have investigated the dynamics of oscillatory coherence throughout the prefrontal-hippocampal-reuniens network in a touchscreen-based working memory task. We found that coherence at distinct frequencies evolved depending on phase and difficulty of the task. During choice, the reuniens did not participate in enhanced prefrontal-hippocampal theta but in gamma coherence. Strikingly, the reuniens was strongly embedded in performance-related increases in beta coherence, suggesting the execution of top-down control. In addition, we show that during working memory maintenance the prefrontal-hippocampal-reuniens network displays performance-related delay activity.
工作记忆需要在数秒的时间尺度上维持与任务相关的信息并对其进行执行控制。空间工作记忆依赖于海马体（用于表征空间）与前额叶皮质（用于执行控制）之间的相互作用。有人提出海马体到前额叶皮质的单突触投射起到了这种相互作用的作用。然而，连接性和失活实验表明， reuniens核在海马体 - 前额叶通信中起关键作用。我们在基于触摸屏的工作记忆任务中研究了前额叶 - 海马体 - reuniens网络中振荡相干性的动态变化。我们发现，不同频率的相干性会根据任务的阶段和难度而演变。在选择过程中，reuniens核不参与增强的前额叶 - 海马体θ波相干性，而是参与γ波相干性。引人注目的是，reuniens核强烈地嵌入与表现相关的β波相干性增加中，这表明执行了自上而下的控制。此外，我们表明，在工作记忆维持期间，前额叶 - 海马体 - reuniens网络表现出与表现相关的延迟活动。
