Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine.
Department of Veterans Affairs, Nashville, Tennessee, USA.
Curr Opin Nephrol Hypertens. 2021 May 1;30(3):275-279. doi: 10.1097/MNH.0000000000000696.
The aim of this study was to summarize recent findings about the role of the epidermal growth factor receptor (EGFR) in acute kidney injury and in progression of chronic kidney injury.
There is increasing evidence that EGFR activation occurs as a response to either ischemic or toxic kidney injury and EGFR signalling plays an important role in recovery of epithelial integrity. However, with incomplete recovery or in conditions predisposing to progressive glomerular and tubulointerstitial injury, aberrant persistent EGFR signalling is a causal mediator of progressive fibrotic injury. New studies have implicated activation of HIPPO/YAP signalling as a component of EGFR's actions in the kidney. There is also new evidence for sex disparities in kidney EGFR expression and activation after injury, with a male predominance that is mediated by androgens.
There is increasing evidence for an important role for EGFR signalling in mediation of kidney injury, raising the possibility that interruption of the signalling cascade could limit progression of development of progressive kidney fibrosis.
本研究旨在总结表皮生长因子受体 (EGFR) 在急性肾损伤和慢性肾损伤进展中的作用的最新发现。
越来越多的证据表明，EGFR 的激活是对缺血或毒性肾损伤的反应，EGFR 信号在恢复上皮完整性方面发挥着重要作用。然而，在不完全恢复或易发生进行性肾小球和肾小管间质损伤的情况下，异常持续的 EGFR 信号是进行性纤维性损伤的因果介质。新的研究表明，HIPPO/YAP 信号的激活是 EGFR 在肾脏中作用的一个组成部分。在损伤后，肾脏中 EGFR 的表达和激活也存在性别差异的新证据，雄激素介导的男性优势。
越来越多的证据表明 EGFR 信号在介导肾损伤中起着重要作用，这增加了中断信号级联反应可能限制进行性肾纤维化发展的可能性。
