Pahuja Sangeeta, Jain Sonal, Nain Manupriya, Goel Ruchika, Sehgal Shivali, Jain Manjula
Department of Immunohematology and Blood Transfusion, Lady Hardinge Medical College, Connaught Place, New Delhi, India.
Asian J Transfus Sci. 2020 Jul-Dec;14(2):137-141. doi: 10.4103/ajts.AJTS_9_19. Epub 2020 Dec 19.
Prevalence of rhesus (Rh) and Kell antigens in a population vary with race, ethnicity, and geographical location. With advances in immunohematology, non-D antigens, and their corresponding antibodies are increasingly being found to be culprits for alloimmunization.
Assessment of the phenotype of Rh and Kell blood group antigen in the healthy donor population from North India was done, and estimation of the frequencies of these alleles in our population was performed.
The most common antigen in the North Indian donor population was "e" (95.6%) followed by "C" (89.6%), "c" (57.7%), and "E" (17.29%) in that order. The most prevalent phenotype in the Indian population was found to be "CDe" followed by "CcDe" and "CcDEe." "K" antigen was found to be positive in 1.81% of the population.
Knowledge of the Rh antigen profiles in a given population can be very helpful in formulating transfusion guidelines specific to a particular population with an aim to minimize the cost and maximize the benefits. With this aim in mind and considering the problems encountered in developing countries like ours, we conducted Rh and Kell antigen profiling of donors. Comparative analysis with other population studies and implications for transfusion protocols is evaluated.
Assessment of Rhesus antigen profile of a particular population is useful to develop cost effective ways of providing maximum benefits of blood transfusion with least resources.
恒河猴（Rh）和凯尔（Kell）抗原在人群中的流行率因种族、民族和地理位置而异。随着免疫血液学的进展，越来越多地发现非D抗原及其相应抗体是同种免疫的罪魁祸首。
对来自印度北部健康献血人群的Rh和Kell血型抗原表型进行评估，并对我们人群中这些等位基因的频率进行估计。
在印度北部献血人群中最常见的抗原依次为“e”（95.6%）、“C”（89.6%）、“c”（57.7%）和“E”（17.29%）。在印度人群中最常见的表型是“CDe”，其次是“CcDe”和“CcDEe”。发现1.81%的人群中“K”抗原呈阳性。
了解特定人群中的Rh抗原谱对于制定针对特定人群的输血指南非常有帮助，目的是将成本降至最低并使效益最大化。出于这个目的，并考虑到像我们这样的发展中国家遇到的问题，我们对献血者进行了Rh和Kell抗原分析。评估了与其他人群研究的比较分析以及对输血方案的影响。
评估特定人群的Rh抗原谱有助于开发具有成本效益的方法，以最少的资源提供输血的最大效益。
