印度献血者人群中 Rh、Duffy、Kell、Kidd 和 MNSs 血型抗原的流行情况。
Prevalence of Rh, Duffy, Kell, Kidd & MNSs blood group antigens in the Indian blood donor population.
机构信息
Department of Transfusion Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
出版信息
Indian J Med Res. 2013 Mar;137(3):521-6.
BACKGROUND & OBJECTIVES: Little data are available regarding the frequencies of the blood group antigens other than ABO and RhD in the Indian population. Knowledge of the antigen frequencies is important to assess risk of antibody formation and to guide the probability of finding antigen-negative donor blood, which is especially useful when blood is required for a patient who has multiple red cell alloantibodies. This study was carried out to determine the frequencies of the D, C, c, E, e, K, k, Fy(a), Fy(b), Jk(a), Jk(b), M, N, S and s antigens in over 3,000 blood donors.
METHODS
Samples from randomly selected blood donors from Delhi and nearby areas (both voluntary and replacement) were collected for extended antigen typing during the period January 2009 to January 2010. Antigens were typed via automated testing on the Galileo instrument using commercial antisera.
RESULTS
A total of 3073 blood samples from donors were phenotyped. The prevalence of these antigens was found to be as follows in %: D: 93.6, C: 87, c: 58, E: 20, e: 98, K: 3.5, k: 99.97, F(a) : 87.4, Fy(b) : 57.6, Jk(a) : 81.5, Jk(b) : 67.4, M: 88.7, N: 65.4, S: 54.8 and s: 88.7.
INTERPRETATION & CONCLUSIONS: This study found the prevalence of the typed antigens among Indian blood donors to be statistically different to those in the Caucasian, Black and Chinese populations, but more similar to Caucasians than to the other racial groups.
背景与目的
在印度人群中，除了 ABO 和 RhD 血型抗原外，其他血型抗原的频率数据较少。了解抗原频率对于评估抗体形成的风险以及指导寻找抗原阴性供体血液的概率非常重要，特别是当患者需要输注具有多种红细胞同种抗体的血液时。本研究旨在确定 3000 多名献血者中 D、C、c、E、e、K、k、Fy(a)、Fy(b)、Jk(a)、Jk(b)、M、N、S 和 s 抗原的频率。
方法
2009 年 1 月至 2010 年 1 月期间，从德里及周边地区（包括志愿献血者和替补献血者）随机选择献血者采集样本，用于进行扩展抗原分型。采用商业抗血清，在 Galileo 仪器上通过自动化检测进行抗原分型。
结果
共对 3073 份献血者样本进行了表型分析。这些抗原的流行率如下：D：93.6%、C：87%、c：58%、E：20%、e：98%、K：3.5%、k：99.97%、F(a)：87.4%、Fy(b)：57.6%、Jk(a)：81.5%、Jk(b)：67.4%、M：88.7%、N：65.4%、S：54.8%和 s：88.7%。
解释与结论
本研究发现，与高加索人、黑人和中国人相比，印度献血者的血型抗原流行率存在统计学差异，但与高加索人更为相似，而与其他种族群体的差异更大。
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