Celsing F, Ekblom B, Sylvén C, Everett J, Astrand P O
Department of Physiology III, Karolinska Institute, Stockholm, Sweden.
Acta Med Scand. 1988;223(5):451-7. doi: 10.1111/j.0954-6820.1988.tb15897.x.
The influence of chronic iron deficiency anaemia on myoglobin content, maximal enzyme activities and capillarization in the human skeletal muscle was investigated. Muscle samples from musculus vastus lateralis were screened in an Indonesian population. The causes of iron deficiency were chronic intestinal bleeding or repeated pregnancy combined with low iron intake. The maximal activities of iron-dependent and non-iron-dependent glycolytic and oxidative enzymes as well as myoglobin showed similar values in the iron-deficient group and the matched control group. The activities of the oxidative enzymes in both the iron-deficient group and the controls were lower, however, compared even to untrained Swedish subjects. The capillary density was essentially within a normal range in both groups. It is concluded that chronic iron deficiency anaemia of a moderate or severe degree, with Hb concentrations of about 80-100 g.1(-1), does not cause an impaired biochemical function of the human skeletal muscle.
研究了慢性缺铁性贫血对人体骨骼肌肌红蛋白含量、最大酶活性和毛细血管化的影响。在印度尼西亚人群中对股外侧肌的肌肉样本进行了筛查。缺铁的原因是慢性肠道出血或多次妊娠合并铁摄入量低。缺铁组和匹配的对照组中，铁依赖性和非铁依赖性糖酵解及氧化酶的最大活性以及肌红蛋白显示出相似的值。然而，与未经训练的瑞典受试者相比，缺铁组和对照组中氧化酶的活性都较低。两组的毛细血管密度基本都在正常范围内。得出的结论是，中度或重度慢性缺铁性贫血，血红蛋白浓度约为80 - 100 g·L⁻¹，不会导致人体骨骼肌生化功能受损。
