缺铁和运动对大鼠肌红蛋白的影响。

Effects of iron deficiency and exercise on myoglobin in rats.

作者信息

McDonald R, Hegenauer J, Sucec A, Saltman P

出版信息

Eur J Appl Physiol Occup Physiol. 1984;52(4):414-9. doi: 10.1007/BF00943372.

Abstract

The effects of iron deficiency and endurance training on muscle myoglobin (Mb), body weights, and blood lactic acid concentration were studied in rats. Fifty animals were divided into four groups: anemic trained (AT), normal trained (NT), anemic sedentary (AS), and normal sedentary (NS). Following 5 weeks of dietary control, the mean hemoglobin values for the AT and AS rats were 0.013 +/- 0.002 mmol X l-1 (8.7 +/- 1.4 g X dl-1) and 0.014 +/- 0.003 mmol X l-1 (9.2 +/- 1.7 g X dl-1) respectively, and did not significantly change throughout the study. AT and NT rats were run on a motor driven treadmill 4 days/week for 6 weeks up to a pre-established time of 90 min. Following the training, body weights of the AT (157 +/- 13 g) and NT (153 +/- 13 g) rats were lower than their respective sedentary groups AS (172 +/- 9 g) and NS (176 +/- 15 g). Resting blood lactic acid concentration following training was lower in both trained groups, AT (3.3 +/- 2.0 mM) and NT (2.3 +/- 1.9 mM) compared to AS (8.2 +/- 2.6 mM) and NS (3.8 +/- 1.6 mM). Training increased Mb concentration in hearts of both the anemic and normal trained groups (AT, 0.66 +/- 0.13 mg X g-1; NT, 0.95 +/- 0.08 mg X g-1) compared to the sedentary groups (AS, 0.44 +/- 0.08 mg X g-1; NS, 0.70 +/- 0.13 mg X g-1). Only the AT rats showed an increase in skeletal muscle Mb. This study provides evidence that myoglobin may limit aerobic metabolism.

摘要

研究了缺铁和耐力训练对大鼠肌肉肌红蛋白（Mb）、体重及血乳酸浓度的影响。50只动物被分为四组：贫血训练组（AT）、正常训练组（NT）、贫血久坐组（AS）和正常久坐组（NS）。经过5周的饮食控制，AT组和AS组大鼠的平均血红蛋白值分别为0.013±0.002 mmol·L⁻¹（8.7±1.4 g·dl⁻¹）和0.014±0.003 mmol·L⁻¹（9.2±1.7 g·dl⁻¹），且在整个研究过程中无显著变化。AT组和NT组大鼠每周4天在电动跑步机上跑步，持续6周，直至达到预先设定的90分钟时间。训练后，AT组（157±13 g）和NT组（153±13 g）大鼠的体重低于各自的久坐组AS组（172±9 g）和NS组（176±15 g）。训练后，两个训练组AT组（3.3±2.0 mM）和NT组（2.3±1.9 mM）的静息血乳酸浓度均低于AS组（8.2±2.6 mM）和NS组（3.8±1.6 mM）。与久坐组（AS组，0.44±0.08 mg·g⁻¹；NS组，0.70±0.13 mg·g⁻¹）相比，训练增加了贫血和正常训练组大鼠心脏中的Mb浓度（AT组，0.66±0.13 mg·g⁻¹；NT组，0.95±0.08 mg·g⁻¹）。只有AT组大鼠的骨骼肌Mb有所增加。本研究提供了证据表明肌红蛋白可能会限制有氧代谢。