睡眠呼吸暂停与皮肤
Sleep Apnea and Skin.
作者信息
Soundararajan Vinaya, Lor Jennifer, Fishbein Anna B
机构信息
University of Illinois at Chicago, Department of Internal Medicine, Chicago, IL USA.
Ann & Robert H. Lurie Children's Hospital Department of Allergy, Division of Pediatric Allergy & Immunology, Chicago IL, USA.
出版信息
Curr Sleep Med Rep. 2020 Sep;6(3):94-100. doi: 10.1007/s40675-020-00179-7. Epub 2020 Aug 25.
PURPOSE OF THE REVIEW
Skin disease is associated with obstructive sleep apnea (OSA) both epidemiologically and mechanistically. In this review we highlight conditions which have a well-established link to obstructive sleep apnea, such as psoriasis and atopic dermatitis.
RECENT FINDINGS
We describe putative mechanistic links between OSA and skin disease involving inflammatory pathways, obesity, mechanical upper airways obstruction, and hypoxia. In the context of these mechanisms we describe specific skin conditions, and other conditions which are associated with both skin manifestations (including hair/nail findings) and OSA. The risks/ benefits of CPAP in the context of skin disease are also reviewed.
SUMMARY
We conclude that further research is needed to understand the mechanisms behind the associations between OSA and skin disease. Given the frequent co-occurrence of OSA and skin conditions, there would be great benefit for OSA clinical trials to consider improvement in skin disease as an outcome measure.
综述目的
皮肤病在流行病学和发病机制上均与阻塞性睡眠呼吸暂停（OSA）相关。在本综述中，我们重点介绍了与阻塞性睡眠呼吸暂停有明确关联的疾病，如银屑病和特应性皮炎。
最新发现
我们描述了OSA与皮肤病之间可能的发病机制联系，涉及炎症途径、肥胖、上气道机械性阻塞和缺氧。在这些机制的背景下，我们描述了特定的皮肤状况，以及其他与皮肤表现（包括毛发/指甲表现）和OSA相关的状况。还综述了在皮肤病背景下持续气道正压通气（CPAP）的风险/益处。
总结
我们得出结论，需要进一步研究以了解OSA与皮肤病之间关联背后的机制。鉴于OSA与皮肤疾病经常同时出现，OSA临床试验若将改善皮肤病作为一项结局指标，将大有裨益。
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