López-Merino V, Sanchis J, Chorro F J, Garcia-Civera R, Sanjuan R, Morell S, Burguera M
Department of Cardiology, Valencia University Clinic Hospital, Spain.
Am Heart J. 1988 Jun;115(6):1214-21. doi: 10.1016/0002-8703(88)90011-7.
Ten anesthetized dogs were studied in an attempt to provoke partial alterations in atrioventricular (AV) conduction by high-frequency current (HFC) transcatheter ablation. A discharge power (10 to 15 W) was used for less than 5 seconds after reaching complete AV block (CAVB). The catheter was placed within an area having an A/V ratio = 1 with His bundle deflection. If following discharge, no appreciable lengthening an AH, AV nodal block cycle length (Wenckebach point, WP), and/or functional nodal refractory period (FRPAVN) was observed, the procedure was repeated. Four dogs (group I) were killed immediately, and the other six (group II) after 2 to 4 weeks. The AH interval, WP, and FRPAVN were found to prolong significantly following HFC, without variations in HV interval. In group II, two dogs progressed to CAVB, whereas the other four maintained 1:1 AV conduction with AH, WP, and FRPAVN greater than before the power discharge. In conclusion, HFC is an efficient technique to induce partial alterations in AV conduction, since the discharge can be adjusted and the ablation can be localized to specific regions.
对十只麻醉犬进行了研究，试图通过高频电流（HFC）经导管消融引发房室（AV）传导的部分改变。在达到完全性房室传导阻滞（CAVB）后，使用放电功率（10至15瓦）持续不到5秒。将导管放置在A/V比值 = 1且有希氏束偏转的区域内。如果放电后未观察到AH间期、房室结阻滞周期长度（文氏点，WP）和/或功能性结区不应期（FRPAVN）有明显延长，则重复该操作。四只犬（第一组）立即处死，另外六只（第二组）在2至4周后处死。发现HFC后AH间期、WP和FRPAVN显著延长，而HV间期无变化。在第二组中，两只犬进展为CAVB，而另外四只维持1:1房室传导，AH、WP和FRPAVN比放电前更大。总之，HFC是一种诱导房室传导部分改变的有效技术，因为放电可以调节，且消融可局限于特定区域。
