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上皮-间充质转化调节转录因子在抗癌药物耐药中的作用。

The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance.

机构信息

Laboratory of Molecular and Pharmacological Cell Biology, College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea.

出版信息

Arch Pharm Res. 2021 Mar;44(3):281-292. doi: 10.1007/s12272-021-01321-x. Epub 2021 Mar 25.

DOI:10.1007/s12272-021-01321-x
PMID:33768509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8009775/
Abstract

The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs.

摘要

介导上皮细胞向间充质细胞转化的基因表达的复杂协调与癌症的发生和转移有关。作为该过程的主要调节因子，上皮-间充质转化调节转录因子（EMT-TFs）在转移中发挥关键作用。它们在最近关于癌症治疗耐药性的临床前研究中也得到了强调。本综述描述了三种主要的 EMT-TFs（Snail、Twist1 和锌指 E 盒结合同源框 1（ZEB1））的作用，包括与耐药性的关系，以及针对 EMT-TFs 的未来挑战的可能方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/f192391e099d/12272_2021_1321_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/f131edd641ca/12272_2021_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/ab26ab566d3a/12272_2021_1321_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/a8724a530034/12272_2021_1321_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/f192391e099d/12272_2021_1321_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/f131edd641ca/12272_2021_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/ab26ab566d3a/12272_2021_1321_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/a8724a530034/12272_2021_1321_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850f/8009775/f192391e099d/12272_2021_1321_Fig4_HTML.jpg

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