Department of Dermatology, American University of Beirut Medical Centre, Beirut, Lebanon.
Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Clin Exp Pharmacol Physiol. 2021 Sep;48(9):1298-1299. doi: 10.1111/1440-1681.13491. Epub 2021 Mar 25.
Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of a variety of oncological conditions. It has been associated with a spectrum of pigmentary cutaneous side effects. Despite the well-known association of eruptive melanocytic nevi with the use of other tyrosine kinase inhibitors, this phenomenon has not been linked to the administration of imatinib. We present the first case of imatinib-induced eruptive nevi in an 18-year-old patient with acute lymphocytic leukaemia in remission.
甲磺酸伊马替尼是一种用于治疗多种肿瘤疾病的酪氨酸激酶抑制剂。它与一系列色素性皮肤副作用有关。尽管众所周知其他酪氨酸激酶抑制剂的使用与爆发性黑素细胞痣有关,但这种现象与伊马替尼的给药无关。我们报告了首例甲磺酸伊马替尼致 18 岁缓解期急性淋巴细胞白血病患者爆发性痣。