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再生因子（RGTA）技术与抗生素联合使用可改善上肢感染的治疗效果。

ReGeneraTing Agents (rgta) technology combined with antibiotics improves outcomes for infections in the upper limb.

作者信息

Roohi Sharifah Ahmad, Keuylian Zela, Barritault Denis

机构信息

Hand & Upper Limb Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia.

Prince Court Medical Centre Orthopaedic Clinic Kuala Lumpur Malaysia.

出版信息

Clin Case Rep. 2021 Jan 27;9(3):1083-1091. doi: 10.1002/ccr3.3645. eCollection 2021 Mar.

DOI:10.1002/ccr3.3645
PMID:33768787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7981774/
Abstract

A matrix therapy agent marketed as CACIPLIQ20 showed marked improvement in the healing rate of hand infections, including functional recovery. It can be used at both earlier and later stages to promote faster healing and prevent an adverse outcome.

摘要

一种名为CACIPLIQ20的基质治疗剂在手部感染的愈合率方面显示出显著改善，包括功能恢复。它可在早期和晚期使用，以促进更快愈合并防止不良后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/ee65487a6df9/CCR3-9-1083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/a1d11927cb37/CCR3-9-1083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/9258666151be/CCR3-9-1083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/19540a7ac5ab/CCR3-9-1083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/ee65487a6df9/CCR3-9-1083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/a1d11927cb37/CCR3-9-1083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/9258666151be/CCR3-9-1083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/19540a7ac5ab/CCR3-9-1083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/7981774/ee65487a6df9/CCR3-9-1083-g002.jpg

相似文献

1
ReGeneraTing Agents (rgta) technology combined with antibiotics improves outcomes for infections in the upper limb.再生因子（RGTA）技术与抗生素联合使用可改善上肢感染的治疗效果。
Clin Case Rep. 2021 Jan 27;9(3):1083-1091. doi: 10.1002/ccr3.3645. eCollection 2021 Mar.
2
ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.再生因子（RGTA）：一种用于手部创伤和烧伤愈合及改善治疗效果的新选择。
Clin Case Rep. 2019 Feb 17;7(4):619-625. doi: 10.1002/ccr3.2054. eCollection 2019 Apr.
3
ReGeneraTing Agents (RGTA) are a new option to improve amputation outcomes in the recovery of severe hand injuries.再生因子（RGTA）是改善严重手部损伤恢复中截肢结果的一种新选择。
Clin Case Rep. 2018 Sep 14;6(11):2061-2069. doi: 10.1002/ccr3.1797. eCollection 2018 Nov.
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RGTA-based matrix therapy - A new branch of regenerative medicine in locomotion.基于RGTA的基质疗法——运动再生医学的一个新分支。
Joint Bone Spine. 2017 May;84(3):283-292. doi: 10.1016/j.jbspin.2016.06.012. Epub 2016 Sep 20.
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Regenerating matrix-based therapy for chronic wound healing: a prospective within-subject pilot study.基于再生基质的慢性伤口愈合治疗：一项前瞻性自身对照初步研究。
Int Wound J. 2011 Feb;8(1):85-95. doi: 10.1111/j.1742-481X.2010.00748.x. Epub 2010 Nov 16.
6
The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20): a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage.新型基质再生剂 (RGTA、CACICOL20) 可刺激碱烧伤角膜愈合：该生物聚合物可模拟肝素硫酸盐，减少蛋白水解、氧化和硝化损伤。
Histol Histopathol. 2014 Apr;29(4):457-78. doi: 10.14670/HH-29.10.457. Epub 2013 Oct 9.
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RGTA-based matrix therapy in severe experimental corneal lesions: safety and efficacy studies.基于RGTA的基质疗法治疗严重实验性角膜损伤：安全性和有效性研究。
J Fr Ophtalmol. 2013 Nov;36(9):740-7. doi: 10.1016/j.jfo.2013.01.012. Epub 2013 Aug 16.
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RGTA or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients.再生治疗剂（RGTA）或再生剂在再生医学中模拟硫酸乙酰肝素：从概念到治愈患者。
Glycoconj J. 2017 Jun;34(3):325-338. doi: 10.1007/s10719-016-9744-5. Epub 2016 Dec 7.
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RGTA OTR 4120, a heparan sulfate proteoglycan mimetic, increases wound breaking strength and vasodilatory capability in healing rat full-thickness excisional wounds.RGTA OTR 4120，一种硫酸乙酰肝素蛋白聚糖模拟物，可提高愈合中的大鼠全层切除伤口的抗张强度和血管舒张能力。
Wound Repair Regen. 2008 Mar-Apr;16(2):294-9. doi: 10.1111/j.1524-475X.2008.00368.x.
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Matrix therapy with RGTA OTR4120 improves healing time and quality in hairless rats with deep second-degree burns.RGTA OTR4120 基质疗法可改善无毛大鼠深二度烧伤的愈合时间和质量。
Plast Reconstr Surg. 2011 Feb;127(2):541-550. doi: 10.1097/PRS.0b013e318200a910.

本文引用的文献

1
A Predictive Score for Determining Risk of Surgical Site Infection After Orthopaedic Trauma Surgery.骨科创伤手术后手术部位感染风险的预测评分。
J Orthop Trauma. 2019 Oct;33(10):506-513. doi: 10.1097/BOT.0000000000001513.
2
Diabetic Control Predicts Surgical Site Infection Risk in Orthopaedic Trauma Patients.糖尿病控制情况预测骨科创伤患者手术部位感染风险。
J Orthop Trauma. 2019 Oct;33(10):514-517. doi: 10.1097/BOT.0000000000001512.
3
ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.
再生因子（RGTA）：一种用于手部创伤和烧伤愈合及改善治疗效果的新选择。
Clin Case Rep. 2019 Feb 17;7(4):619-625. doi: 10.1002/ccr3.2054. eCollection 2019 Apr.
4
ReGeneraTing Agents (RGTA) are a new option to improve amputation outcomes in the recovery of severe hand injuries.再生因子（RGTA）是改善严重手部损伤恢复中截肢结果的一种新选择。
Clin Case Rep. 2018 Sep 14;6(11):2061-2069. doi: 10.1002/ccr3.1797. eCollection 2018 Nov.
5
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in -infected mice.基于硫酸乙酰肝素模拟物的基质疗法在感染小鼠中进行牙周重建
Heliyon. 2018 Aug 6;4(8):e00719. doi: 10.1016/j.heliyon.2018.e00719. eCollection 2018 Aug.
6
Randomized controlled trial demonstrates the benefit of RGTA® based matrix therapy to treat tendinopathies in racing horses.随机对照试验证明 RGTA® 基质疗法治疗赛马肌腱病的益处。
PLoS One. 2018 Mar 9;13(3):e0191796. doi: 10.1371/journal.pone.0191796. eCollection 2018.
7
RGTA or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients.再生治疗剂（RGTA）或再生剂在再生医学中模拟硫酸乙酰肝素：从概念到治愈患者。
Glycoconj J. 2017 Jun;34(3):325-338. doi: 10.1007/s10719-016-9744-5. Epub 2016 Dec 7.
8
RGTA-based matrix therapy - A new branch of regenerative medicine in locomotion.基于RGTA的基质疗法——运动再生医学的一个新分支。
Joint Bone Spine. 2017 May;84(3):283-292. doi: 10.1016/j.jbspin.2016.06.012. Epub 2016 Sep 20.
9
Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes: A Case Series.一种新型硫酸乙酰肝素模拟敷料对2型糖尿病足及下肢溃疡愈合的疗效：病例系列研究
Int J Low Extrem Wounds. 2016 Mar;15(1):63-7. doi: 10.1177/1534734616629302.
10
In vitro and in vivo evaluation of cord blood hematopoietic stem and progenitor cells amplified with glycosaminoglycan mimetic.用糖胺聚糖模拟物扩增的脐带血造血干细胞和祖细胞的体外和体内评估
Stem Cell Res Ther. 2016 Jan 7;7:3. doi: 10.1186/s13287-015-0267-y.