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再生因子（RGTA）是改善严重手部损伤恢复中截肢结果的一种新选择。

ReGeneraTing Agents (RGTA) are a new option to improve amputation outcomes in the recovery of severe hand injuries.

作者信息

Ahmad Roohi Sharifah, Barritault Denis

机构信息

Dept. of Orthopaedics Faculty of Medicine and Health Sciences University Putra Malaysia Serdang Malaysia.

Hand & Upper Limb Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia.

出版信息

Clin Case Rep. 2018 Sep 14;6(11):2061-2069. doi: 10.1002/ccr3.1797. eCollection 2018 Nov.

DOI:10.1002/ccr3.1797
PMID:30455892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6230612/
Abstract

CACIPLIQ20 was used to accelerate the healing process and stimulate the viability of flaps and skin grafts, thereby improving amputation outcomes. An excellent range of motion was achieved with hardly any contracture or scarring. Pain relief and reduced sensitivity was noted, while healing of bone and tendon also improved, resulting in functional recovery.

摘要

CACIPLIQ20被用于加速愈合过程并刺激皮瓣和皮肤移植的存活能力，从而改善截肢效果。实现了极佳的活动范围，几乎没有挛缩或瘢痕形成。观察到疼痛减轻和敏感度降低，同时骨和肌腱的愈合也得到改善，从而实现功能恢复。

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1
ReGeneraTing Agents (RGTA) are a new option to improve amputation outcomes in the recovery of severe hand injuries.再生因子（RGTA）是改善严重手部损伤恢复中截肢结果的一种新选择。
Clin Case Rep. 2018 Sep 14;6(11):2061-2069. doi: 10.1002/ccr3.1797. eCollection 2018 Nov.
2
ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.再生因子（RGTA）：一种用于手部创伤和烧伤愈合及改善治疗效果的新选择。
Clin Case Rep. 2019 Feb 17;7(4):619-625. doi: 10.1002/ccr3.2054. eCollection 2019 Apr.
3
ReGeneraTing Agents (rgta) technology combined with antibiotics improves outcomes for infections in the upper limb.再生因子（RGTA）技术与抗生素联合使用可改善上肢感染的治疗效果。
Clin Case Rep. 2021 Jan 27;9(3):1083-1091. doi: 10.1002/ccr3.3645. eCollection 2021 Mar.
4
RGTA-based matrix therapy - A new branch of regenerative medicine in locomotion.基于RGTA的基质疗法——运动再生医学的一个新分支。
Joint Bone Spine. 2017 May;84(3):283-292. doi: 10.1016/j.jbspin.2016.06.012. Epub 2016 Sep 20.
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RGTA or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients.再生治疗剂（RGTA）或再生剂在再生医学中模拟硫酸乙酰肝素：从概念到治愈患者。
Glycoconj J. 2017 Jun;34(3):325-338. doi: 10.1007/s10719-016-9744-5. Epub 2016 Dec 7.
6
RGTA-based matrix therapy in severe experimental corneal lesions: safety and efficacy studies.基于RGTA的基质疗法治疗严重实验性角膜损伤：安全性和有效性研究。
J Fr Ophtalmol. 2013 Nov;36(9):740-7. doi: 10.1016/j.jfo.2013.01.012. Epub 2013 Aug 16.
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[Pilot study of a new matrix therapy agent (RGTA OTR4120) in treatment-resistant corneal ulcers and corneal dystrophy].一种新型基质疗法药物（RGTA OTR4120）治疗难治性角膜溃疡和角膜营养不良的初步研究
J Fr Ophtalmol. 2008 May;31(5):465-71. doi: 10.1016/s0181-5512(08)72462-8.
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Heparan Sulfate Mimetics Accelerate Postinjury Skeletal Muscle Regeneration.硫酸乙酰肝素模拟物加速损伤后骨骼肌再生。
Tissue Eng Part A. 2019 Dec;25(23-24):1667-1676. doi: 10.1089/ten.TEA.2019.0058. Epub 2019 Nov 15.
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Managing chronic, nonhealing wounds stalled in the inflammatory phase: a case series using a novel matrix therapy, CACIPLIQ20.治疗停滞在炎症阶段的慢性难愈合伤口：一项使用新型基质疗法CACIPLIQ20的病例系列研究
Br J Community Nurs. 2019 Sep 1;24(Sup9):S33-S37. doi: 10.12968/bjcn.2019.24.Sup9.S33.
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The healing of alkali-injured cornea is stimulated by a novel matrix regenerating agent (RGTA, CACICOL20): a biopolymer mimicking heparan sulfates reducing proteolytic, oxidative and nitrosative damage.新型基质再生剂 (RGTA、CACICOL20) 可刺激碱烧伤角膜愈合：该生物聚合物可模拟肝素硫酸盐，减少蛋白水解、氧化和硝化损伤。
Histol Histopathol. 2014 Apr;29(4):457-78. doi: 10.14670/HH-29.10.457. Epub 2013 Oct 9.

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ReGeneraTing Agents (rgta) technology combined with antibiotics improves outcomes for infections in the upper limb.再生因子（RGTA）技术与抗生素联合使用可改善上肢感染的治疗效果。
Clin Case Rep. 2021 Jan 27;9(3):1083-1091. doi: 10.1002/ccr3.3645. eCollection 2021 Mar.
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Matrix therapy is a cost-effective solution to reduce amputation risk and improve quality of life: pilot and case studies.

本文引用的文献

1
RGTA or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients.再生治疗剂（RGTA）或再生剂在再生医学中模拟硫酸乙酰肝素：从概念到治愈患者。
Glycoconj J. 2017 Jun;34(3):325-338. doi: 10.1007/s10719-016-9744-5. Epub 2016 Dec 7.
2
RGTA-based matrix therapy - A new branch of regenerative medicine in locomotion.基于RGTA的基质疗法——运动再生医学的一个新分支。
Joint Bone Spine. 2017 May;84(3):283-292. doi: 10.1016/j.jbspin.2016.06.012. Epub 2016 Sep 20.
3
Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes: A Case Series.
基质疗法是一种降低截肢风险和提高生活质量的经济有效的解决方案：试点研究和案例分析。
Regen Med Res. 2019;7:2. doi: 10.1051/rmr/190002. Epub 2019 Dec 10.
4
ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.再生因子（RGTA）：一种用于手部创伤和烧伤愈合及改善治疗效果的新选择。
Clin Case Rep. 2019 Feb 17;7(4):619-625. doi: 10.1002/ccr3.2054. eCollection 2019 Apr.
一种新型硫酸乙酰肝素模拟敷料对2型糖尿病足及下肢溃疡愈合的疗效：病例系列研究
Int J Low Extrem Wounds. 2016 Mar;15(1):63-7. doi: 10.1177/1534734616629302.
4
Refractory sickle cell leg ulcer: is heparan sulphate a new hope?难治性镰状细胞性腿部溃疡：硫酸乙酰肝素是新希望吗？
Int Wound J. 2016 Feb;13(1):35-8. doi: 10.1111/iwj.12217. Epub 2014 Feb 21.
5
A systematic review of outcomes of revision amputation treatment for fingertip amputations.指尖截肢翻修术治疗结局的系统评价。
Hand (N Y). 2013 Jun;8(2):139-45. doi: 10.1007/s11552-012-9487-0.
6
RGTA-based matrix therapy in severe experimental corneal lesions: safety and efficacy studies.基于RGTA的基质疗法治疗严重实验性角膜损伤：安全性和有效性研究。
J Fr Ophtalmol. 2013 Nov;36(9):740-7. doi: 10.1016/j.jfo.2013.01.012. Epub 2013 Aug 16.
7
Diabetes-impaired wound healing is improved by matrix therapy with heparan sulfate glycosaminoglycan mimetic OTR4120 in rats.糖尿病导致的伤口愈合不良可通过硫酸乙酰肝素糖胺聚糖模拟物 OTR4120 的基质疗法得到改善。
Diabetes. 2012 Oct;61(10):2633-41. doi: 10.2337/db11-1329. Epub 2012 Jun 20.
8
Heparan sulfate glycosaminoglycan mimetic improves pressure ulcer healing in a rat model of cutaneous ischemia-reperfusion injury.硫酸乙酰肝素糖胺聚糖类似物可改善皮肤缺血再灌注损伤大鼠模型的压疮愈合。
Wound Repair Regen. 2011 Jul-Aug;19(4):505-14. doi: 10.1111/j.1524-475X.2011.00704.x. Epub 2011 Jun 7.
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[Basement of matrix therapy in regenerative medicine by RGTA(®): From fundamental to plastic surgery].[再生医学中基于RGTA(®)的基质疗法：从基础到整形外科]
Ann Chir Plast Esthet. 2010 Oct;55(5):413-20. doi: 10.1016/j.anplas.2010.09.002.
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[First applications of matrix therapy in plastic and aesthetic surgery].[基质疗法在整形美容外科中的首次应用]
Ann Chir Plast Esthet. 2010 Oct;55(5):421-8. doi: 10.1016/j.anplas.2010.07.011. Epub 2010 Sep 24.