Fang Yu, Qin Zhiming
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Turk Gogus Kalp Damar Cerrahisi Derg. 2021 Jan 13;29(1):52-60. doi: 10.5606/tgkdc.dergisi.2021.19586. eCollection 2021 Jan.
This study aims to evaluate the surgical treatment outcomes of giant mediastinal tumors.
Between July 2013 and July 2018, medical data of a total of 31 patients (26 males, 5 females; mean age 27.7±8.2 years; range, 18 to 56 years) who underwent radical surgery for a giant mediastinal tumor in our center and 47 cases (26 males, 21 females; mean age 45.4±16.7 years; range, 19 to 62 years) of giant mediastinal tumors retrieved from the National Center for Biotechnology Information database were retrospectively reviewed. Two-year overall survival and disease-free survival rates of the patients were evaluated.
All patients underwent radical surgery (R0 resection). Symptoms caused by giant mediastinal tumors were relieved after radical surgery during follow-up. The two-year overall survival and disease-free survival rates were 100% and 86.7%, respectively, indicating a good prognosis. The surgical procedures for malignancies were more difficult than those for benign pathologies.
Radical surgery is the mainstay for treatment of giant mediastinal tumors to relieve symptoms in a short period of time and to achieve a good prognosis for up to two years, regardless of adjuvant therapy. The surgical route should be cautiously planned before radical surgery to reduce complications.
本研究旨在评估巨大纵隔肿瘤的外科治疗效果。
回顾性分析2013年7月至2018年7月期间在本中心接受巨大纵隔肿瘤根治性手术的31例患者（男26例，女5例；平均年龄27.7±8.2岁；范围18至56岁）以及从美国国立生物技术信息中心数据库检索到的47例巨大纵隔肿瘤患者（男26例，女21例；平均年龄45.4±16.7岁；范围19至62岁）的医疗数据。评估患者的两年总生存率和无病生存率。
所有患者均接受了根治性手术（R0切除）。随访期间，根治性手术后巨大纵隔肿瘤引起的症状得到缓解。两年总生存率和无病生存率分别为100%和86.7%，预后良好。恶性肿瘤的手术操作比良性病变更为困难。
根治性手术是治疗巨大纵隔肿瘤的主要方法，可在短时间内缓解症状并在两年内取得良好预后无论是否进行辅助治疗。在根治性手术前应谨慎规划手术路径以减少并发症。
