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一名心脏移植患者出现腹泻的新型冠状病毒肺炎病例。

COVID-19 presenting with diarrhea in a heart transplant patient.

作者信息

Işık Mehmet Emirhan, Günay Deniz, Aksüt Mehmet, Menekşe Şirin, Uygun-Kızmaz Yeşim, Kırali Mehmet Kaan

机构信息

Department of Infectious Diseases and Clinical Microbiology, Koşuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul, Turkey.

Department of Cardiovascular Surgery, Koşuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul, Turkey.

出版信息

Turk Gogus Kalp Damar Cerrahisi Derg. 2021 Jan 13;29(1):119-121. doi: 10.5606/tgkdc.dergisi.2021.20420. eCollection 2021 Jan.

Abstract

A 55-year-old man who underwent bicaval orthotopic heart transplantation nine months earlier presented with complaints of diarrhea and oliguria. Laboratory findings showed pancytopenia and an elevated creatinine level. Cyclosporine and mycophenolate mofetil were discontinued, and the patient received only everolimus. As he was immunosuppressed and had atypical symptoms during the COVID-19 pandemic, reverse transcriptase-polymerase chain reaction testing was performed, which yielded a positive result. Treatment with hydroxychloroquine and favipiravir were initiated. Although the patient suffered from acute renal failure, his condition showed an improvement after hydration plus a five-day antiviral treatment and, then, treatment was stopped. His COVID-19 test was negative after 10 days of follow-up and treatment, and he was discharged with cyclosporin and mycophenolate mofetil.

摘要

一名9个月前接受双腔原位心脏移植的55岁男性,出现腹泻和少尿症状。实验室检查结果显示全血细胞减少和肌酐水平升高。停用环孢素和霉酚酸酯,患者仅接受依维莫司治疗。由于他在新冠疫情期间免疫功能低下且有非典型症状,进行了逆转录聚合酶链反应检测,结果呈阳性。开始使用羟氯喹和法匹拉韦治疗。尽管患者患有急性肾衰竭,但在补液加为期5天的抗病毒治疗后病情有所改善,随后停止治疗。随访和治疗10天后,他的新冠病毒检测呈阴性,出院时继续使用环孢素和霉酚酸酯。

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COVID-19 presenting with diarrhea in a heart transplant patient.一名心脏移植患者出现腹泻的新型冠状病毒肺炎病例。
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Heart transplant recipient survivor from COVID-19: The first case of Turkey.新冠病毒肺炎康复的心脏移植受者:土耳其首例。
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本文引用的文献

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First cases of COVID-19 in heart transplantation from China.中国心脏移植中首例新冠病毒病病例。
J Heart Lung Transplant. 2020 May;39(5):496-497. doi: 10.1016/j.healun.2020.03.006. Epub 2020 Mar 17.
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Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

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