BCG 疫苗接种预防 COVID-19 的潜力：一种分析方法。
BCG vaccination potential for COVID-19: an analytical approach.
机构信息
Pharmacology Department, College of Medicine, Minia University, Minya, Egypt.
出版信息
Hum Vaccin Immunother. 2021 Aug 3;17(8):2448-2450. doi: 10.1080/21645515.2021.1885281. Epub 2021 Mar 26.
Abstract
In order to assess the possible protective potential of BCG vaccination as regards to COVID-19, we have analyzed BCG vaccination status and SARS CoV-2 morbidity and mortality in China and we have also examined other studies performed in other countries to assess the potential of booster doses of BCG vaccination for adults. We have concluded that BCG vaccination early in life is highly unlikely to be a tool that might prevent SARS CoV-2 infection in adults. Furthermore, we have suggested that BCG vaccination potential benefit to decrease COVID-19 morbidity and mortality in children is confounded by many factors, e.g. age limitations of exposure and other vaccines. However, BCG vaccination booster doses in adults might be of protective value until the results of well-designed clinical trials are published to confirm, or refute, this potential.
摘要
为了评估卡介苗（BCG）接种对 COVID-19 的可能保护潜力，我们分析了中国的 BCG 接种状况以及 SARS-CoV-2 的发病率和死亡率，并研究了其他国家进行的评估成人 BCG 加强针接种潜力的研究。我们得出的结论是，BCG 疫苗在生命早期接种不太可能成为预防成人感染 SARS-CoV-2 的工具。此外，我们还认为，BCG 疫苗对降低儿童 COVID-19 发病率和死亡率的潜在益处受到许多因素的影响，例如暴露的年龄限制和其他疫苗。然而，在设计良好的临床试验结果公布之前，成人接种 BCG 加强针可能具有保护价值，以确认或反驳这种潜力。
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