School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, College of National Sciences, Kyungpook National University, Daegu, Republic of Korea.
Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea.
Pathog Glob Health. 2021 Jul;115(5):292-299. doi: 10.1080/20477724.2021.1906562. Epub 2021 Mar 26.
Over the past 20 years, humankind has encountered three severe coronavirus outbreaks. Currently ongoing, COVID-19 (coronavirus disease 2019) was declared a pandemic due to its massive impact on global health and the economy. Numerous scientists are working to identify efficacious therapeutic agents for COVID-19, although treatment ability has yet to be demonstrated. The SUMO (small ubiquitin-like modifier) system has diverse roles in viral manipulation, but the function of SUMO in coronaviruses is still unknown. The objective of this review article is to present recently published data suggesting contributions of the host SUMO system to coronavirus infection. These findings underscore the potential of SUMO as a novel target for anti-coronavirus therapy, and the need for a deeper understanding of coronavirus pathology to prepare and prevail against the current and emerging coronavirus outbreaks.
在过去的 20 年中，人类遭遇了三次严重的冠状病毒爆发。目前正在流行的 COVID-19（2019 年冠状病毒病）因其对全球健康和经济的巨大影响而被宣布为大流行。许多科学家正在努力寻找针对 COVID-19 的有效治疗药物，尽管尚未证明其治疗能力。SUMO（小泛素样修饰物）系统在病毒操纵中具有多种作用，但 SUMO 在冠状病毒中的功能尚不清楚。本文综述的目的是介绍最近发表的数据，表明宿主 SUMO 系统对冠状病毒感染的贡献。这些发现强调了 SUMO 作为新型抗冠状病毒治疗靶点的潜力，并且需要更深入地了解冠状病毒病理学，以准备和应对当前和新出现的冠状病毒爆发。
