Department of Community Health and Epidemiology (Dr Khan); Department of Oncology (Dr Ahmed, Dr Zaidi); Canadian Center for Health and Safety in Agriculture (Dr Karunanayake); Distinguished Research Chair, University of Saskatchewan (Dr Dosman); President and CEO, Agrivita Canada Inc. (Dr Dosman); Department of Community Health and Epidemiology (Dr Pahwa), Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, SK, Canada.
J Occup Environ Med. 2021 Apr 1;63(4):e203-e214. doi: 10.1097/JOM.0000000000002161.
This study aimed to determine the prevalence of hormone-related cancers (HRCs) among Saskatchewan rural dwellers and explore associated risk factors.
Data were analyzed from the Saskatchewan Rural Health Study (SRHS), which was a prospective cohort (2010 to 2014). Completed questionnaires were obtained from 4624 (2797) households, with information about 8261 (4867) individuals more than or equal to 18 years at baseline (follow-up). The crude prevalence of HRCs was calculated using appropriate formulae. Adjusted prevalence was calculated using logistic regression based on the generalized estimating equation (GEE).
Crude prevalence of HRCs was 3.0% at the baseline. Variables significantly associated with HRCs were: exposure to radiation comprising ultraviolet radiation from sunlight as well as ionizing radiation (odds ratio [OR] 3.39; 95% confidence interval [CI]: 2.23, 4.84), previous history of cancer in sibling (OR = 1.51, 95% CI: 1.11, 2.07) and in father (OR = 1.37; 95% CI = 1.01, 1.86).
The study informs the Saskatchewan Health Region for health care resource allocation.
本研究旨在确定萨斯喀彻温省农村居民中激素相关癌症（HRC）的患病率，并探讨相关的危险因素。
本研究的数据来源于萨斯喀彻温省农村健康研究（SRHS），这是一项前瞻性队列研究（2010 年至 2014 年）。从 4624 个（2797 个）家庭中获得了完整的调查问卷，其中有 8261 名（4867 名）年龄在 18 岁及以上的个体在基线（随访）时提供了信息。使用适当的公式计算 HRC 的粗患病率。使用基于广义估计方程（GEE）的逻辑回归计算调整后的患病率。
HRC 的粗患病率在基线时为 3.0%。与 HRC 显著相关的变量包括：暴露于辐射，包括阳光中的紫外线辐射和电离辐射（比值比 [OR] 3.39；95%置信区间 [CI]：2.23，4.84）、兄弟姐妹（OR=1.51，95%CI：1.11，2.07）和父亲（OR=1.37；95%CI：1.01，1.86）有癌症病史。
本研究为萨斯喀彻温省卫生区的医疗资源分配提供了信息。
