Castle D, Bernstein R
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
Am J Med Genet. 1988 Mar;29(3):549-56. doi: 10.1002/ajmg.1320290312.
We report on cytogenetic analysis of 688 couples experiencing two or more first- and/or second-trimester abortions (less than 20 weeks). The overall abnormality rate was 6.83% (47 couples). However, exclusion of those anomalies not generally accepted as being causal in spontaneous abortion leaves an abnormality rate of only 2.33% (16 couples). We discuss the significance of balanced translocations, inversions, sex chromosome aneuploidies, and mosaicisms thereof in the causation of multiple abortions.
我们报告了对688对经历过两次或更多次孕早期和/或孕中期流产（少于20周）的夫妇进行的细胞遗传学分析。总体异常率为6.83%（47对夫妇）。然而，排除那些一般不被认为是自然流产病因的异常情况后，异常率仅为2.33%（16对夫妇）。我们讨论了平衡易位、倒位、性染色体非整倍体及其嵌合体在多次流产病因中的意义。
