红细胞膜隆起的pH依赖性行为。II. 在中度酸血症和碱血症条件下的发生情况。

PH-dependent behavior of erythrocyte membrane elevations. II Occurrence in moderate acidemic and alkalemic conditions.

作者信息

Goekoop J G, Spies F, Wisse D M, Vrielink R, De Vries E, Van Kempen G M

出版信息

Cell Biol Int Rep. 1978 Jul;2(4):397-402. doi: 10.1016/0309-1651(78)90026-7.

Abstract

Changes of the number of red cell membrane elevations revealed by freeze-etch electron microscopy are pH-dependent in vitro and in vivo. In healthy volunteers a decrease of the number of red cell surfaces with elevations was observed under moderate acidemic and alkalemic conditions. These changes were different in patients with Huntington's chorea and affective psychotic disorders. Elevations of the red cell membrane with the same diameter can be demonstrated in ultrathin sections, if sodium azide is added during the fixation procedure.

摘要

冷冻蚀刻电子显微镜显示的红细胞膜隆起数量变化在体外和体内均依赖于pH值。在健康志愿者中，在中度酸血症和碱血症条件下观察到有隆起的红细胞表面数量减少。这些变化在亨廷顿舞蹈病和情感性精神障碍患者中有所不同。如果在固定过程中加入叠氮化钠，在超薄切片中可以显示出相同直径的红细胞膜隆起。