Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark; Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark.
Clin Neurophysiol. 2021 May;132(5):1083-1088. doi: 10.1016/j.clinph.2021.01.026. Epub 2021 Mar 10.
To test the hypothesis that significant changes in the occurrence of interictal epileptiform electroencephalography (EEG) discharges (EDs) are associated with seizures: while some EDs are pro-convulsive, increasing at seizure-occurrence, others are protective, showing decrease related to seizures.
We analyzed 102 consecutive, long-term video-EEG monitoring sessions, from 98 patients. Using a semi-automated spike-detection method, we quantified the occurrence of EDs, grouped according to their location and morphology (clusters) and we constructed graphical representation of data, showing changes in time of the spiking patterns (spike-histograms). We compared the spike-histograms with the time-points of the seizures (pre-, peri- and postictal changes).
Totally 179 ED-clusters were identified. Modulation of the spiking pattern, associated with seizures, was observed in 66 clusters (37%), from 47 patients (48%). Most of these changes (40 clusters; 61%) were related to increase in the spiking-pattern.
Changes in spiking-pattern were associated with more than one third of the EDs. Both increasing and decreasing patterns were observed.
EDs are more often pro-convulsive, with increasing spiking patterns associated with seizures. However, in more than one third of the ED clusters modulated by seizures, the spiking pattern decreased, raising the possibility of an anticonvulsive function of these discharges.
验证以下假设，即癫痫发作间期脑电图（EEG）放电（ED）的发生显著变化与癫痫发作有关：一些 ED 是促惊厥的，随着癫痫发作而增加，而另一些 ED 是保护的，与癫痫发作相关的放电减少。
我们分析了 98 例连续的 102 例长程视频-EEG 监测病例。使用半自动化的棘波检测方法，我们根据位置和形态（簇）对 ED 发生进行了量化分组，并构建了数据的图形表示，显示了棘波模式的时间变化（棘波直方图）。我们将棘波直方图与癫痫发作的时间点（发作前、发作中和发作后变化）进行了比较。
总共确定了 179 个 ED 簇。在 47 名患者（48%）的 66 个簇（37%）中观察到与癫痫发作相关的棘波模式调节。这些变化中的大多数（40 个簇；61%）与棘波模式的增加有关。
与超过三分之一的 ED 相关的棘波模式发生了变化。观察到增加和减少的模式。
ED 更常具有促惊厥作用，与癫痫发作相关的棘波模式增加。然而，在三分之一以上的由癫痫发作调制的 ED 簇中，棘波模式减少，这增加了这些放电具有抗惊厥作用的可能性。
