Weissman B A, Blaze P A, Ingles S, Wheeler N
Jules Stein Eye Institute, University of California School of Medicine, Los Angeles.
Am J Optom Physiol Opt. 1988 Apr;65(4):272-6. doi: 10.1097/00006324-198804000-00005.
Three hydrogel contact lenses of measured oxygen transmissibility (Dk/L = 20, 12, and 6 x 10(-9) cm ml O2/s ml mm Hg, respectively) were used to induce central corneal swelling as measured by optical pachometry in five human subjects under open-eye conditions (8 h wear). Both contact lenses with higher Dk/L values induced mean central corneal swelling of about 1.5%. The lower Dk/L lens induced a mean central corneal swelling of 2.2%. However, statistical analysis of the differences in central corneal swelling between the lens-wearing and the control eyes indicates that swelling induced by the higher Dk/L lenses is not identical, and indicates that even a Dk/L of 20 x 10(-9) is insufficient to reduce corneal swelling to zero. This suggests that the "critical oxygen tension" (COT) could be in excess of 20 to 40 mm Hg, but not necessarily as high as 70 mm Hg.
使用三种测量了透氧性的水凝胶隐形眼镜（Dk/L分别为20、12和6×10⁻⁹ cm·ml O₂/s·ml·mmHg），在五名受试者睁眼条件下（佩戴8小时），通过光学角膜厚度测量法来诱导中央角膜肿胀。两种具有较高Dk/L值的隐形眼镜均诱导中央角膜平均肿胀约1.5%。较低Dk/L值的隐形眼镜诱导中央角膜平均肿胀2.2%。然而，对佩戴隐形眼镜的眼睛和对照眼之间中央角膜肿胀差异的统计分析表明，较高Dk/L值的隐形眼镜所诱导的肿胀并不相同，并且表明即使Dk/L为20×10⁻⁹也不足以将角膜肿胀降低至零。这表明“临界氧张力”（COT）可能超过20至40 mmHg，但不一定高达70 mmHg。
