Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Trends Pharmacol Sci. 2021 May;42(5):385-397. doi: 10.1016/j.tips.2021.02.004. Epub 2021 Mar 23.
Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery of macrocyclic peptides. This article reviews the current approaches for generating macrocyclic peptide libraries using mRNA display and highlights some recent examples of ribosomal incorporation of nonproteinogenic amino acids into macrocyclic peptides.
大环肽是一类很有前途的化合物，通常可以与具有挑战性的治疗靶点结合。展示技术，如 mRNA 展示，允许高效发现大环肽。本文综述了使用 mRNA 展示生成大环肽文库的当前方法，并强调了核糖体掺入非天然氨基酸到大环肽中的一些最新实例。
