McQuillan P J, Morgan B A, Ramwell J
Department of Anaesthesia, Newcastle General Hospital.
Anaesthesia. 1988 Apr;43(4):301-4.
The death under general anaesthesia of a child with Adriamycin cardiomyopathy is reported. The acute, subacute and chronic cardiotoxic effects of Adriamycin are discussed and the risk factors for chronic Adriamycin cardiomyopathy presented, with particular reference to cumulative dosage of Adriamycin. The insidious onset of impairment of cardiac function is stressed and suggestions for anaesthetic management outlined.
本文报道了一名患有阿霉素心肌病的儿童在全身麻醉下死亡的病例。讨论了阿霉素的急性、亚急性和慢性心脏毒性作用，并介绍了慢性阿霉素心肌病的危险因素，特别提及了阿霉素的累积剂量。强调了心功能损害的隐匿性发作，并概述了麻醉管理的建议。
