Kaduk B, Seiler G
Dtsch Med Wochenschr. 1977 Dec 9;102(49):1813-7. doi: 10.1055/s-0028-1105604.
Doxorubicin at a dose of 470 mg/m2 body surface, was administered to a 15-year-old boy with metastasising osteosarcoma. The cumulative dose caused severe "secondary congestive cardiomyopathy", which ended fatally, although the cumulative dose was below the recommended limit of 550 mg/m2. No other treatment for the tumour had been given. Postmortem examination revealed obliterative lesions in the intramural coronary vessels and electron-microscopy showed all the features of a cardiomyopathy at cellular level.
给一名患有转移性骨肉瘤的15岁男孩静脉注射了阿霉素，剂量为每平方米体表面积470毫克。尽管累积剂量低于550毫克/平方米的推荐极限，但累积剂量还是导致了严重的“继发性充血性心肌病”，最终导致了致命的后果。该肿瘤未接受其他治疗。尸检显示壁内冠状动脉血管有闭塞性病变，电子显微镜检查显示在细胞水平上具有心肌病的所有特征。
