Centre for Dermatology Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom.
St. John's Institute of Dermatology, King's College London, London, United Kingdom; NIHR Biomedical Research Centre, Guys and St Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
J Invest Dermatol. 2021 Aug;141(8):1872-1878. doi: 10.1016/j.jid.2021.02.746. Epub 2021 Mar 24.
A stratified medicine approach for the treatment of psoriasis promises greater certainty of clinical decision making through prediction of response on the basis of clinical, pharmacological, and -omics data from an individual patient. As yet, there is no predictive model for treatment response in routine clinical use for psoriasis. The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) Consortium is a United Kingdom Medical Research Council‒funded, academic‒industrial stratified medicine consortium established with the objective of discovering the predictors and stratifiers of response of psoriasis to biologic therapies. A showcase meeting was convened and attended by 80 stakeholders at the Royal College of Physicians, London, United Kingdom on 18 November 2019. The purpose was to disseminate the research findings from the PSORT consortium discovered thus far. This report summarizes the presentations made on the day and the significant advances made by PSORT toward a stratified medicine approach to the management of psoriasis.
分层医学方法有望通过预测个体患者的临床、药理学和组学数据来提高临床决策的确定性。然而，目前还没有用于常规临床治疗银屑病的预测模型。银屑病分层以优化相关治疗（PSORT）联盟是一个由英国医学研究理事会资助的学术-工业分层医学联盟，旨在发现银屑病对生物治疗反应的预测因子和分层因素。2019 年 11 月 18 日，在英国伦敦皇家医师学院召开了一次展示会，有 80 名利益相关者出席。会议的目的是传播迄今为止 PSORT 联盟的研究发现。本报告总结了当天的演讲内容以及 PSORT 在分层医学方法治疗银屑病方面取得的重大进展。
