Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA; Medical Scientist Training Program, Yale School of Medicine, New Haven, Connecticut, USA.
Yale College, Yale University, New Haven, Connecticut, USA.
J Invest Dermatol. 2023 Aug;143(8):1412-1422. doi: 10.1016/j.jid.2023.04.005. Epub 2023 Jun 20.
Immunologically targeted therapies have revolutionized the treatment of inflammatory dermatoses, including atopic dermatitis and psoriasis. Although immunologic biomarkers hold great promise for personalized classification of skin disease and tailored therapy selection, there are no approved or widely used approaches for this in dermatology. This review summarizes the translational immunologic approaches to measuring treatment-relevant biomarkers in inflammatory skin conditions. Tape strip profiling, microneedle-based biomarker patches, molecular profiling from epidermal curettage, RNA in situ hybridization tissue staining, and single-cell RNA sequencing have been described. We discuss the advantages and limitations of each and open questions for the future of personalized medicine in inflammatory skin disease.
免疫靶向治疗已经彻底改变了炎症性皮肤病的治疗方法，包括特应性皮炎和银屑病。虽然免疫生物标志物为皮肤病的个性化分类和针对性治疗选择提供了巨大的希望，但在皮肤科领域，还没有经过批准或广泛使用的方法。本综述总结了用于测量炎症性皮肤疾病中治疗相关生物标志物的转化免疫方法。已经描述了胶带条分析、基于微针的生物标志物贴片、表皮刮除术的分子分析、RNA 原位杂交组织染色和单细胞 RNA 测序。我们讨论了每种方法的优缺点以及炎症性皮肤病个性化医学的未来的开放性问题。
